Evidence map›Paper›PMID 33827528›Full record

ArticleBMC urology2021

Association between severity of prenatally diagnosed hydronephrosis and receipt of surgical intervention postnatally among patients seen at a fetal-maternal center.

Zoë G Baker, Arthi Hannallah, Melissa Trabold, Danielle Estell, Cherry Deng, Andy Y Chang, S Scott Sparks, Roger De Filippo, Evalynn Vasquez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zoë G BakerDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA. zobaker@chla.usc.edu.ORCID http://orcid.org/0000-0003-4929-1964
Arthi HannallahDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Melissa TraboldDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Danielle EstellKeck School of Medicine of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Cherry DengThomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA, USA.
Andy Y ChangDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
S Scott SparksDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Roger De FilippoDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Evalynn VasquezDivision of Urology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
University of Southern California · USChildren's Hospital of Los Angeles · USUniversity of the Pacific · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHydronephrosis (HN) is the most common abnormality detected on prenatal ultrasound. This study sought to stratify outcomes of patients by severity of prenatal HN with postnatal outcomes.

methodsThis was a retrospective review of patients referred to a tertiary care fetal-maternal clinic with diagnosis of prenatal HN from 2004 to 2019. HN severity was categorized as mild, moderate, or severe. Data were analyzed to determine the association between HN severity and surgical intervention. Decision for surgery was based on factors including history of multiple urinary tract infections, evidence of renal scarring, and/or reduced renal function. Surgery-free survival time was represented by the Kaplan-Meier method, and hazard ratios were calculated using the log-rank test.

results131 kidneys among 101 infants were prenatally diagnosed with hydronephrosis; 35.9% had mild HN, 29.0% had moderate HN, and 35.1% had severe HN. 8.5% of patients with mild HN, 26.3% of patients with moderate HN, and 65.2% of patients with severe HN required surgery. Patients with severe HN were 12.2 (95% CI 6.1-24.4; p < 0.001) times more likely to undergo surgery for HN than patients with mild HN and 2.9 (95% CI 1.5-5.3; p = 0.003) times more likely to undergo surgery than patients with moderate HN. Patients with moderate HN were 4.3 times more likely to require surgery than patients with mild HN (95% CI 1.5-12.9; p = 0.01). Median age at surgery was 11.8 months among patients with mild HN (IQR 11.7-14.1 months), 6.6 months among patients with moderate HN (IQR 4.2-16.4 months), and 5.4 months among patients with severe HN (3.7-12.4 months).

conclusionAmong this cohort of referrals from a fetal-maternal clinic, severity of HN correlated with increased likelihood of surgical intervention. Continued assessment of patients with prenatal HN should be evaluated to best determine the role of the pediatric urologist in cases of prenatal HN.

Indexed as

Ultrasonography, PrenatalFemaleHumansHydronephrosisInfant, NewbornMalePregnancyPrenatal CareRetrospective StudiesSeverity of Illness IndexTertiary Care CentersTreatment OutcomeDiagnosisFetalHydronephrosisPrenatalSurgery

Identifiers

PMID33827528
PMCPMC8028200
OpenAlexW3151167740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.