Trial reportBMC pediatrics2021
A home-based, post-discharge early intervention program promotes motor development and physical growth in the early preterm infants: a prospective, randomized controlled trial.
Trial report in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05334550 (Effectiveness of Home Based Early Intervention of Extremely Premature Infant by Parent), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Home Based Early Intervention of Extremely Premature Infant by Parent
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Effects on Weight Gain and Length of Hospital Stay of Day and Night-Cycled Light Exposure in Premature Infants: A Meta-Analysis.The journal of nursing research : JNR · 2025Pooled it
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of a home-based, post-discharge early intervention program for very preterm infants in reducing parental stress: a randomized controlled trial.BMC public health · 2024Trial
- Early developmental support for preterm infants based on exploratory behaviors: A parallel randomized controlled study.Brain and behavior · 2023Trial
- Father and Sibling Involvement in Home Rehabilitation: Longitudinal Effects on Infant Development and Maternal Wellbeing in Bulawayo, Zimbabwe.Child: care, health and development · 2026Observational
- Telehealth Delivery of the Homeostasis-Enrichment-Plasticity Approach for Premature Infants With Developmental Risks: Exploratory Feasibility Study.Journal of medical Internet research · 2026Article
- Interventions to support parents, families and caregivers in caring for preterm or low birth weight infants at home: A systematic review and meta-analysis.PLOS global public health · 2026Article
- Effects of multisensory interventions initiated during NICU hospitalization on neurodevelopment in preterm infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Development and Validation of a Nurse-Led Developmental Intervention Package to Improve the Neurodevelopmental Outcomes of Preterm Babies in Neonatal Intensive Care Unit.Pediatric discovery · 2025Article
- An Integrated Review of Transitional Care for Families of Pre-Term Infants.Healthcare (Basel, Switzerland) · 2024Review
- [Research hotspots in post-discharge follow-up management of preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe implementation of early intervention (EI) in medical settings is time-consuming and resource-intensive, which limits its extensive use. In 2018, the Chinese Eugenics Association developed a home-based, post-discharge EI program. This study aims at evaluating the impact of this EI program on neurodevelopment and physical growth of early preterm infants.
methodsThis study was a prospective, partially blinded, randomized controlled trial (RCT), followed by an open phase. A total of 73 infants born at 28
resultsFrom T0 to T1, both groups had significant improvements in all outcome measures (all p < 0.001). A 30-day EI program was more effective in improving TIMP than standard care (from 53.12 ± 8.79 to 83.50 ± 11.85 in EI-SC group vs from 50.52 ± 8.64 to 75.97 ± 13.44 in SC-EI group, F = 4.232, p = 0.044). EI-SC group also had greater improvements in length, weight, and head circumference than SC-EI group (all p < 0.05). From T0 to T2, there was no significant difference regarding the improvements in all outcomes between the groups (all p > 0.05). At the endpoint of T2, the EI-SC and SC-EI group had similar TIMP and anthropometric measures, but much higher than the reference group (all p < 0.05).
conclusionsThese findings demonstrated that a home-based, post-discharge EI program in this study was a practical approach to promote motor development and physical growth in early preterm infants.
trial registrationCHICTR, CTR1900028330, registered December 19, 2019, https:// http://www.chictr.org.cn/showproj.aspx?proj=45706.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.