SynthesisInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2021
Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.
Synthesis in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
183 citing papers in PubMed, 314 citations in OpenAlex.
- Injectable radiopaque targets for cone-beam CT guided histotripsy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026Article
- Recent developments and prospects in locoregional therapy of hepatocellular carcinoma.Abdominal radiology (New York) · 2026Review
- Integrating Histotripsy into Chemoimmunotherapy for Oligometastatic Recurrent Extrahepatic Cholangiocarcinoma: Case Report.Cardiovascular and interventional radiology · 2026Article
- Characterization of Bubble Cloud Formation and Tissue Ablation Using a High-Frequency Endoscopic Histotripsy System.Ultrasound in medicine & biology · 2026Article
- Ultrasound-Guided Histotripsy for Non-Invasive Treatment of Ex Vivo Soft Tissue Tumors: Preclinical Feasibility Study.Annals of surgical oncology · 2026Article
- Histotripsy for Liver Tumors: Breakthrough or Hype?Annals of surgical oncology · 2026Article
- Review
- A Comprehensive Review of Minimally Invasive Surgical Therapies for Voiding Dysfunction in Benign Prostatic Hyperplasia: Past Failures, Contemporary Successes and Future Innovations.Current urology reports · 2026Review
- Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications.Smart molecules : open access · 2026Review
- Focused Ultrasound-Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri-Focally Localized Glioblastoma Cells.International journal of cancer · 2026Article
- Listening to Immunotherapy - Ultrasound and Photoacoustic Imaging Strategies to Guide and Enhance Cancer Treatments.Molecular imaging and biology · 2026Review
- Article
- Safety and Efficacy of Histotripsy Treatments Near Implanted Metallic Fiducials and Endovascular Coils in Phantoms and in an In Vivo Swine Model.Ultrasound in medicine & biology · 2026Article
- A Magnetic Resonance-Compatible Fiberoptic Temperature Sensor for Measuring Focused Ultrasound-Induced Heating Without Artifacts.Ultrasound in medicine & biology · 2026Article
- Review
- Review
- Ultrasound-Induced Cavitation as Biological Constraint Focusing: A Phenomenological Bioengineering Model for Sonoporation, Sonodynamic Therapy, Drug Delivery, and Histotripsy.Bioengineering (Basel, Switzerland) · 2026Article
- Revisiting the Immunological Landscape of Locoregional Therapies for Gastrointestinal Cancers: A Shift Toward Interventional Immuno-Oncology.Current oncology reports · 2026Review
- Inter-observer variability in breast segmentation and its impact on focused ultrasound thermal therapy modeling.Physics in medicine and biology · 2026Article
- Closing the global surgical divide: histotripsy, a pathway to universal access?Annals of medicine and surgery (2012) · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the histotripsy ablation zone is absorbed by the body within 1-2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment. Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases. Three human clinical trials have been undertaken using histotripsy for the treatment of benign prostatic hyperplasia, liver cancer, and calcified valve stenosis. This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.