Evidence map›Paper›PMID 33827271›Full record

ArticleTissue engineering. Part A2021

Chondrogenesis of Mesenchymal Stem Cells through Local Release of TGF-β3 from Heparinized Collagen Biofabric.

Hyungjin Jung, Phillip McClellan, Jean F Welter, Ozan Akkus

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. 3D Culture of MSCs for Clinical Application.Bioengineering (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hyungjin JungDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Phillip McClellanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Jean F WelterDepartment of Biology, Case Western Reserve University, Cleveland, Ohio, USA.
Ozan AkkusDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Case Western Reserve University · US

Funding

TR&D-4: Growing Tissue in the Scalable, Modular, Automated, and Closed (SMAC) FoundryP41EB021911 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI HARIHARA BASKARAN · 2016 to 2026
$13.9M
Cartilage Repair by Condensed Mesenchymal Stem Cell Delivery via Collagen FabricR21AR068516 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI AKKUS, OZAN · 2017 to 2018
$384k
NIAMS NIH HHS R21 AR068516NIBIB NIH HHS P41 EB021911
6 · The paper itself

Abstract

Osteoarthritic degeneration of cartilage is a major social health problem. Tissue engineering of cartilage using combinations of scaffold and mesenchymal stem cells (MSCs) is emerging as an alternative to existing treatment options such as microfracture, mosaicplasty, allograft, autologous chondrocyte implantation, or total joint replacement. Induction of chondrogenesis in high-density pellets of MSCs is generally attained by soluble exogenous TGF-β3 in culture media, which requires lengthy

Indexed as

ChondrogenesisMesenchymal Stem CellsTissue ScaffoldsCollagenHeparinHumansTextilesTransforming Growth Factor beta3CollagenHeparinTransforming Growth Factor beta3cartilage regenerationchondrogenesiscollagen scaffoldheparin conjugationhuman mesenchymal stem cellsTGF-β3

Identifiers

PMID33827271
PMCPMC8827115
OpenAlexW3143402335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.