Evidence map›Paper›PMID 33827255›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation.

Estibaliz Castillero, Daniel P Howsmon, Bruno V Rego, Samuel J Keeney, Kathryn H Driesbaugh, Takayuki Kawashima, Yingfei Xue (薛应騛), Chiara Camillo, Isaac George, Robert C Gorman and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Estibaliz CastilleroDepartment of Surgery, Columbia University Irving Medical Center, New York, NY (E.C., Y.X., C.C., I.G., G.F.).
Daniel P HowsmonDepartment of Biomedical Engineering, James T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin (D.P.H., B.V.R., M.S.S.).
Bruno V RegoDepartment of Biomedical Engineering, James T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin (D.P.H., B.V.R., M.S.S.).
Samuel J KeeneyDepartment of Pediatrics, Children's Hospital of Philadelphia, PA (S.J.K., K.H.D., R.J.L.).
Kathryn H DriesbaughDepartment of Pediatrics, Children's Hospital of Philadelphia, PA (S.J.K., K.H.D., R.J.L.).
Takayuki KawashimaGorman Cardiovascular Research Group, Department of Surgery, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia (T.K., R.C.G., J.H.G.).
Yingfei Xue (薛应騛)Department of Surgery, Columbia University Irving Medical Center, New York, NY (E.C., Y.X., C.C., I.G., G.F.).
Chiara CamilloDepartment of Surgery, Columbia University Irving Medical Center, New York, NY (E.C., Y.X., C.C., I.G., G.F.).
Isaac GeorgeDepartment of Surgery, Columbia University Irving Medical Center, New York, NY (E.C., Y.X., C.C., I.G., G.F.).
Robert C GormanGorman Cardiovascular Research Group, Department of Surgery, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia (T.K., R.C.G., J.H.G.).
Joseph H GormanGorman Cardiovascular Research Group, Department of Surgery, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia (T.K., R.C.G., J.H.G.).
Michael S SacksDepartment of Biomedical Engineering, James T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin (D.P.H., B.V.R., M.S.S.).
Robert J LevyDepartment of Pediatrics, Children's Hospital of Philadelphia, PA (S.J.K., K.H.D., R.J.L.).
Giovanni FerrariDepartment of Surgery, Columbia University Irving Medical Center, New York, NY (E.C., Y.X., C.C., I.G., G.F.).
Columbia University Irving Medical Center · USChildren's Hospital of Philadelphia · USTranslational Therapeutics (United States) · USTwitter (United States) · USThe University of Texas at Austin · US

Funding

Surgery to Prevent Post Infarction Ventricular RemodelingR01HL063954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C · 2001 to 2018
$9.8M
Supplement to Serotonin Signaling in Mitral Valve Homeostasis, Maintenance and RestorationR01HL131872 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Giovanni Ferrari, Robert J Levy · 2016 to 2026
$7.7M
Quantitative Methods for Optimizing IMR RepairR01HL073021 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C, SACKS, MICHAEL S · 2004 to 2022
$7.6M
Remodeling potential of the mitral valve following surgical repairR01HL119297 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI GORMAN, JOSEPH H, SACKS, MICHAEL S · 2013 to 2017
$6.6M
NHLBI NIH HHS R01 HL063954NHLBI NIH HHS R01 HL073021NHLBI NIH HHS R01 HL119297NHLBI NIH HHS R01 HL131872
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsBone Morphogenetic Protein 4Cells, CulturedDisease Models, AnimalFemaleGene Regulatory NetworksLeukocyte Common AntigensMaleMitral ValveMitral Valve InsufficiencyMyocardial InfarctionProtein Interaction MapsSheep, DomesticSignal TransductionTranscriptomeTransforming Growth Factor beta1Bone Morphogenetic Protein 4Leukocyte Common AntigensTransforming Growth Factor beta1heart ventriclesmitral valvemitral valve insufficiencymyocardial infarctiontransforming growth factor beta

Identifiers

PMID33827255
PMCPMC8159877
OpenAlexW3148231751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.