Evidence map›Paper›PMID 33827091›Full record

Trial reportNeonatology2021

Effect of Bias Gas Flow on Tracheal Cytokine Concentrations in Ventilated Extremely Preterm Infants: A Randomized Controlled Trial.

Katinka P Bach, Carl A Kuschel, Nicola Patterson, Hana Skwish, Sabine Huth, Hui Hui Phua, Frank H Bloomfield

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neonatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07101419 (Longer Pressure Rise Time During Mechanical Ventilation of Extremely Preterm Infants), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07101419 nanot yet recruitingnot on this mapstarted 2027, after this paper: background citation

Longer Pressure Rise Time During Mechanical Ventilation of Extremely Preterm Infants: A Randomised Crossover Trial

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2027 to 2028Enrolled68ConditionsRespiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature InfantArmsLong PRT, Short PRT
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Katinka P BachStarship Children's Hospital, Auckland District Health Board, Auckland, New Zealand.
Carl A KuschelRoyal Women's Hospital, Melbourne, Victoria, Australia.
Nicola PattersonMiddlemore Hospital, Counties Manukau Health, Auckland, New Zealand.
Hana SkwishSargent College of Health and Rehabilitation Sciences, Boston University, Boston, Massachusetts, USA.
Sabine HuthStarship Children's Hospital, Auckland District Health Board, Auckland, New Zealand.
Hui Hui PhuaLiggins Institute, University of Auckland, Auckland, New Zealand.
Frank H BloomfieldLiggins Institute, University of Auckland, Auckland, New Zealand.
Auckland District Health Board · NZUniversity of Auckland · NZBoston University · USMiddlemore Hospital · NZRoyal Women's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to determine whether ventilator bias gas flow affects tracheal aspirate (TA) cytokine concentrations in ventilated extremely preterm infants.

methodsThis is a randomized controlled trial in a tertiary neonatal unit in New Zealand. Preterm infants (<28 weeks' gestation/<1,000 g) requiring intubation in the first 7 days after birth were randomized to bias gas flows of 4 or 10 L/min. Cytokine concentrations in TA and plasma were measured at 24, 72, and 120 h after the onset of ventilation. The primary outcome measure was concentration of interleukin (IL)-8 in TA 24 h after the onset of mechanical ventilation.

resultsBaseline demographics were similar in babies randomized to 4 (n = 50) and 10 (n = 45) L/min bias gas flow. TA IL-8 concentrations were not different between groups. Plasma IL-8 concentrations decreased over time (p < 0.05). Respiratory support and incidence of bronchopulmonary dysplasia at 36 weeks' corrected gestational age were similar between groups. Fewer babies ventilated at 4 L/min developed necrotizing enterocolitis (NEC) ≥ stage 2 (n = 0 vs. n = 5; p = 0.02) and fewer died (n = 1 vs. n = 5, p = 0.06).

conclusionsLower bias gas flow in ventilated extremely preterm infants did not alter TA cytokine concentrations but the lower incidence of NEC and mortality warrants further investigation.

Indexed as

Bronchopulmonary DysplasiaEnterocolitis, NecrotizingCytokinesGestational AgeHumansInfant, Extremely PrematureInfant, NewbornCytokinesInterleukin-8RheotraumaShear stressVentilator-induced lung injury

Identifiers

PMID33827091
PMCPMC8491472
OpenAlexW3139785259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.