ArticleNeuron2021
Spatial integration during active tactile sensation drives orientation perception.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- Diminished Signal-to-Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- Late-term moderate prenatal alcohol exposure impairs tactile, but not spatial, discrimination in a T-maze continuous performance task in juvenile rats.Behavioural brain research · 2024Article
- Article
- Callosal inputs generate side-invariant receptive fields in the barrel cortex.Science advances · 2023Article
- Effects of visual deprivation on the injury of lower extremities among functional ankle instability patients during drop landing: A kinetics perspective.Frontiers in physiology · 2022Article
- Multiplexed Representation of Itch and Mechanical and Thermal Sensation in the Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas.Frontiers in neuroanatomy · 2021Article
- Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice.Neuron · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Active haptic sensation is critical for object identification, but its neural circuit basis is poorly understood. We combined optogenetics, two-photon imaging, and high-speed behavioral tracking in mice solving a whisker-based object orientation discrimination task. We found that orientation discrimination required animals to summate input from multiple whiskers specifically along the whisker arc. Animals discriminated the orientation of the stimulus per se as their performance was invariant to the location of the presented stimulus. Populations of barrel cortex neurons summated across whiskers to encode each orientation. Finally, acute optogenetic inactivation of the barrel cortex and cell-type-specific optogenetic suppression of layer 4 excitatory neurons degraded performance, implying that infragranular layers alone are not sufficient to solve the task. These data suggest that spatial summation over an active haptic array generates representations of an object's orientation, which may facilitate encoding of complex three-dimensional objects during active exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.