ArticleCell reports2021
Slower prefrontal metastable dynamics during deliberation predicts error trials in a distance discrimination task.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- History bias and its perturbation of the stimulus representation in the macaque prefrontal cortex.The Journal of physiology · 2026Article
- Out of the single-neuron straitjacket: Neurons within assemblies change selectivity and their reconfiguration underlies dynamic coding.The Journal of physiology · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.bioRxiv : the preprint server for biology · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.PloS one · 2025Article
- Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.PLoS computational biology · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.bioRxiv : the preprint server for biology · 2024Article
- Identifying and modulating neural signatures of stress susceptibility and resilience enables control of anhedonia.Research square · 2024Article
- Connecting the dots in the zona incerta: A study of neural assemblies and motifs of inter-area coordination in mice.iScience · 2024Article
- Multistability in neural systems with random cross-connections.Biological cybernetics · 2023Article
- Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network.bioRxiv : the preprint server for biology · 2023Article
- Temporal progression along discrete coding states during decision-making in the mouse gustatory cortex.PLoS computational biology · 2023Article
- Error-related brain state analysis using electroencephalography in conjunction with functional near-infrared spectroscopy during a complex surgical motor task.Brain informatics · 2022Article
- Metastable dynamics of neural circuits and networks.Applied physics reviews · 2022Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Cortical activity related to erroneous behavior in discrimination or decision-making tasks is rarely analyzed, yet it can help clarify which computations are essential during a specific task. Here, we use a hidden Markov model (HMM) to perform a trial-by-trial analysis of the ensemble activity of dorsolateral prefrontal cortex (PFdl) neurons of rhesus monkeys performing a distance discrimination task. By segmenting the neural activity into sequences of metastable states, HMM allows us to uncover modulations of the neural dynamics related to internal computations. We find that metastable dynamics slow down during error trials, while state transitions at a pivotal point during the trial take longer in difficult correct trials. Both these phenomena occur during the decision interval, with errors occurring in both easy and difficult trials. Our results provide further support for the emerging role of metastable cortical dynamics in mediating complex cognitive functions and behavior.
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