ArticleEnvironmental health perspectives2021
Rare, Protein-Altering Variants in
Erratum issuedOpen access · diamondAbstract read
In one paragraph
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Arsenic Methyltransferase Function in Inorganic Arsenic Biotransformation: Implications for Health Risks and Disease Development.Biological trace element research · 2026Review
- Article
- Article
- Genetics, Epigenetics, and the Environment: Are Precision Medicine, Provider Compassion, and Social Justice Effective Public Health Measures to Mitigate Disease Risk and Severity?International journal of environmental research and public health · 2024Review
- Returning personal genetic information on susceptibility to arsenic toxicity to research participants in Bangladesh.Environmental research · 2024Article
- Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water.Scientific reports · 2023Article
- Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations.PLoS genetics · 2023Article
- Inherited genetic effects on arsenic metabolism: A comparison of effects on arsenic species measured in urine and in blood.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 9 institutions in 1 country.
Dayana A DelgadoDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Meytal ChernoffDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Lei HuangCenter for Research Informatics, UChicago, Chicago, Illinois, USA.
Lin TongDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Lin ChenDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Farzana JasmineDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Justin ShinkleDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Shelley A ColeTexas Biomedical Research Institute, San Antonio, Texas, USA.
Karin HaackTexas Biomedical Research Institute, San Antonio, Texas, USA.
Jack KentTexas Biomedical Research Institute, San Antonio, Texas, USA.
Jason UmansGeorgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA.
Lyle G BestMissouri Breaks Industries Research, Inc., Timber Lake, South Dakota, USA.
Heather NelsonSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Donald Vander GriendDepartment of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.
Joseph GrazianoMailman School of Public Health, Columbia University, New York City, New York, USA.
Muhammad G KibriyaDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Ana Navas-AcienMailman School of Public Health, Columbia University, New York City, New York, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Habibul AhsanDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Brandon L PierceDepartment of Public Health Sciences, University of Chicago (UChicago), Chicago, Illinois, USA.
Chicago Department of Public Health · USTexas Biomedical Research Institute · USColumbia University · USDartmouth College · USGeorgetown-Howard Universities Center for Clinical and Translational Science · USMissouri Breaks Industries Research (United States) · USUniversity of Chicago · USUniversity of Illinois Chicago · USUniversity of Minnesota · US
Funding
Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6MVARIATION IN BIOACCUMULATION AND BIOMAGNIFICATION OF METALS IN NORTHERN US LAKESP42ES007373 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1995 to 2019
$52.0MTrue Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7MRelation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7MThe Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2MChemoprevention of arsenic-induced skin cancerR01CA107431 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2005 to 2014
$17.3MSTRONG HEART STUDY (SHS): OUHSC COORDINATING CENTER - TASK AREA B (B.1 AND B.3)75N92019D00027 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, YING · 2019 to 2025
$15.5MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MCARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6MNONMELANOMA SKIN CANCER IN NEW HAMPSHIRER01CA057494 · NCI · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 1993 to 2015
$10.9MSTRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9MCARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9MFIC NIH HHS R24 TW009555NCI NIH HHS R01 CA057494NCI NIH HHS R01 CA107431NHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS R01 HL090863NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIA NIH HHS T32 AG051146NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES027792NIEHS NIH HHS P42 ES007373NIEHS NIH HHS P42 ES010349NIEHS NIH HHS R01 ES021367NIEHS NIH HHS R01 ES023834NIEHS NIH HHS R01 ES025216NIEHS NIH HHS R21 ES024834NIEHS NIH HHS R24 ES028532NIEHS NIH HHS R35 ES028379NIGMS NIH HHS P20 GM104416NIGMS NIH HHS R25 GM109439
Abstract
backgroundCommon genetic variation in the arsenic methyltransferase (
objectivesWe estimated the impact of rare, protein-coding variation in
methodsWe generated targeted DNA sequencing data for the coding regions of
resultsWe identified 23 carriers of rare-protein-altering DISCUSSION: Rare, protein-altering variants in
Indexed as
ArsenicCacodylic AcidLongitudinal StudiesMethyltransferasesPolymorphism, Single NucleotideArsenicCacodylic AcidMethyltransferases
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.