Evidence map›Paper›PMID 33826401›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin).

Wei Ying, Kechun Tang, Ennio Avolio, Jan M Schilling, Teresa Pasqua, Matthew A Liu, Hongqiang Cheng, Hong Gao, Jing Zhang, Sumana Mahata and 12 more

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes.Frontiers in clinical diabetes and healthcare · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Catestatin in Cardiovascular Diseases.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Serum Catestatin Level as a Stratification Assessment Tool in Non-Critical COVID-19 Patients.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Wei Ying *Department of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Kechun Tang *VA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
Ennio AvolioDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Jan M SchillingVA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
Teresa PasquaVA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
Matthew A LiuDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Hongqiang ChengDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China (H.C.).
Hong GaoDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Jing ZhangDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Sumana MahataDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Myung S KoDepartment of Chemistry and Biochemistry (M.S.K., G.G.), University of California San Diego, La Jolla.
Gautam BandyopadhyayDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Soumita DasDepartment of Pathology (S.D.), University of California San Diego, La Jolla.
David M RothVA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
Debashis SahooDepartment of Pediatrics (D.S.), University of California San Diego, La Jolla.
Nicholas J G WebsterVA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
Farah SheikhDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Gourisankar GhoshDepartment of Chemistry and Biochemistry (M.S.K., G.G.), University of California San Diego, La Jolla.
Hemal H PatelVA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
Pradipta GhoshDepartment of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
Geert van den BogaartDepartment of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, the Netherlands (G.v.d.B.).
Sushil K MahataVA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).

Funding

Vector Production CoreP01HL066941 · NHLBI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI HAMMOND, H. KIRK · 2001 to 2017
$34.8M
Macrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9M
Caveolae, mitochondria, and cardiac protection.R01HL091071 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H · 2008 to 2019
$3.8M
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal InflammationR01AI141630 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pradipta Ghosh · 2019 to 2026
$3.2M
Summer Student Research on the Application of Boolean AnalysisR01GM138385 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2020 to 2023
$2.0M
Uncovering New Functions of CSN6 in Cardiac Desmosomal Biology and DiseaseR01HL142251 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHEIKH, FARAH · 2018 to 2021
$1.6M
Precision therapeutics of inflammatory bowel disease guided by Boolean logicUG3TR003355 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2020 to 2022
$937k
Application of Boolean Networks to discover stem and progenitor cellsR00CA151673 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAHOO, DEBASHIS · 2014 to 2016
$717k
BLR&D Research Career Scientist Award ApplicationIK6BX005224 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI WEBSTER, NICHOLAS J · 2020 to 2025
–
BLRD VA I01 BX001963BLRD VA I01 BX003934BLRD VA I01 BX004848BLRD VA IK6 BX005224NCATS NIH HHS UG3 TR003355NCI NIH HHS R00 CA151673NHLBI NIH HHS P01 HL066941NHLBI NIH HHS R01 HL091071NHLBI NIH HHS R01 HL142251NIAID NIH HHS R01 AI141630NIAID NIH HHS R01 AI155696NIGMS NIH HHS R01 GM138385
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsCardiotonic AgentsChromogranin AHypertensionHypertrophy, Left VentricularImmunosuppression TherapyMacrophagesMaleMiceMice, KnockoutPeptide FragmentsCardiotonic AgentsChromogranin Achromogranin A (344-364)Peptide Fragmentsbone marrowchromogranin Ahypertensioninflammationmacrophages

Identifiers

PMID33826401
PMCPMC8116433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.