ArticleAnnals of clinical and translational neurology2021
Subcortical short-term plasticity elicited by deep brain stimulation.
Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Automating Subthalamic Deep Brain Stimulation Programming with Evoked Resonant Neural Activity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Frequency-dependent modulation of evoked potentials during GPi-DBS in pediatric dystonia.Scientific reports · 2025Article
- Paired Deep Brain Stimuli Elicit Short-Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention.Progress in neurobiology · 2025Review
- Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation.Nature communications · 2025Article
- Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.NPJ Parkinson's disease · 2025Review
- The development, use, and challenges of electromechanical tissue stimulation systems.Artificial organs · 2024Review
- Deep brain stimulation pulse sequences to optimally modulate frequency-specific neural activity.Journal of neural engineering · 2024Article
- Directional Stimulus-Evoked Pallidal Electrophysiology in Primary Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Subthalamic Nucleus Stimulation-Induced Local Field Potential Changes in Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics.Neurobiology of disease · 2023Article
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- Alternative patterns of deep brain stimulation in neurologic and neuropsychiatric disorders.Frontiers in neuroinformatics · 2023Review
- Rescue subthalamic stimulation after unsatisfactory outcome of pallidal stimulation in Parkinson's disease: a case series and review.Frontiers in aging neuroscience · 2023Article
- Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson's Disease patients.Frontiers in human neuroscience · 2023Article
- Subthalamic deep brain stimulation of an anatomically detailed model of the human hyperdirect pathway.Journal of neurophysiology · 2022Article
- The impact of pulse timing on cortical and subthalamic nucleus deep brain stimulation evoked potentials.Frontiers in human neuroscience · 2022Article
- Pattern of frustration formation in the functional brain network.Network neuroscience (Cambridge, Mass.) · 2022Article
- Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate local short-term neuroplasticity elicited by subthalamic, thalamic, and pallidal deep brain stimulation (DBS) for movement disorders.
methodsDuring DBS surgery, we delivered pairs of stimulus pulses with both circular and directional leads across 90 interstimulus intervals in 17 participants and recorded local field potentials from unused contacts on the implanted electrode array. We removed the stimulus artifact, validated the neural origin of the underlying signals, and examined short-term plasticity as a function of interstimulus interval and DBS target, using linear mixed effects models.
resultsDBS evokes short latency local field potentials that are readily detected with both circular and directional leads at all stimulation targets (0.31 ± 0.10 msec peak latency, mean ± SD). Peak amplitude, area, and latency are modified strongly by interstimulus interval (P < 0.001) and display absolute and relative refractory periods (0.56 ± 0.08 and 2.94 ± 1.05 msec, respectively). We also identified later oscillatory activity in the subthalamic-pallidal circuit (4.50 ± 1.11 msec peak latency) that displays paired pulse facilitation (present in 5/8 subthalamic, 4/5 pallidal, and 0/6 thalamic trajectories, P = 0.018, Fisher's exact test), and correlates with resting beta frequency power (P < 0.001), therapeutic DBS frequencies, and stimulation sites chosen later for therapy in the ambulatory setting (P = 0.031).
interpretationPaired DBS pulses synchronize local circuit electrophysiology and elicit short-term neuroplasticity in the subthalamic-pallidal circuit. Collectively, these responses likely represent the earliest detectable interaction between the DBS pulse and local neuronal tissue in humans. Evoked subcortical field potentials could serve as a predictive biomarker to guide the implementation of next-generation directional and adaptive stimulation devices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.