Evidence map›Paper›PMID 33826158›Full record

Trial reportJournal of the American Geriatrics Society2021

Frailty implications for exercise participation and outcomes in patients with heart failure.

Alison M Mudge, Anita Pelecanos, Julie A Adsett

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Impact of exercise on the 21Sports medicine and health science · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. The Dual Burden of Frailty and Heart Failure.International journal of heart failure · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Comparing Virtual and Center-Based Cardiac Rehabilitation on Changes in Frailty.International journal of environmental research and public health · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Alison M MudgeDepartment of Internal Medicine and Aged Care, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-0242-2165
Anita PelecanosStatistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Julie A AdsettPhysiotherapy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-0007-9615
QIMR Berghofer Medical Research Institute · AURoyal Brisbane and Women's Hospital · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesFrailty is common in people with heart failure (HF) and associated with poorer outcomes. The aim of this study was to describe the characteristics, exercise participation, and outcomes of frail and not-frail participants enrolled in a randomized trial of exercise training (ET) within a cardiac rehabilitation (CR) program.

designSecondary analysis of EJECTION-HF randomized trial (ACTRN12608000263392).

settingFive HF-specific CR programs in Queensland, Australia.

participantsAdults recently hospitalized with HF.

interventionAll participated in CR including home exercise prescription and monitoring; half were randomized to center-based ET. MEASUREMENTS: A frailty index (FI) was constructed at randomization and 6-month follow-up. Outcomes included ET attendance, change in 6-min walk distance (6MWD), improved FI (>0.09 units) at 6 months, achieving physical activity (PA) guidelines at 6 months, and 12 month all-cause death or readmission.

resultsThe FI was measured in 256 participants at randomization: 110 (43%) were not-frail (FI 0.2 or less), 119 (46%) were frail (FI >0.2 to 0.39), and 27 (11%) were very frail (FI ≥0.4). Frailty was more common with older age, female gender, decompensated HF, worse HF symptoms, and preserved ejection fraction. ET attendance did not differ by frailty group. Participants who were more frail had lower 6WMD at enrollment, but similar improvement over 6 months. Mean FI improved by 0.03 units at 6 months (95% CI 0.02-0.04, p < 0.001). Participants who were more frail had significantly greater improvements in FI compared with not-frail participants and were often able to achieve PA guidelines, both in intervention and control groups. Neither baseline frailty nor intervention was significantly associated with 12-month death or readmission.

conclusionFrail people with HF participating in CR that includes home and/or center-based ET often achieve PA guidelines, and some may have meaningful reductions in frailty.

Indexed as

Cardiac RehabilitationExercise TherapyPatient ComplianceAgedFemaleFrailtyHeart FailureHumansMaleSingle-Blind MethodTreatment Outcomeexercise trainingfrailtyheart failurephysical activity

Identifiers

PMID33826158
OpenAlexW3145038644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.