ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2021
Effect of Methanol Extract of Baobab (Adansonia digitata L.) Fruit Pulp on N
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 8 citations in OpenAlex.
- The Antioxidant and Anti-lipidemic Potential of Angiotensin-converting Enzyme Inhibitor (Ramipril) in L-NAME Hypertensive Rats.Cardiovascular & hematological agents in medicinal chemistry · 2026Article
- A Narrative Review on Plant Extracts for Metabolic Syndrome: Efficacy, Safety, and Technological Advances.Nutrients · 2025Review
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3 authors at 2 institutions in 1 country.
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Abstract
introductionMost available drugs used for management of hypertension have presented a plethora of challenges which genuinely called for development of therapies from natural sources.
aimThis study investigated the effect of methanol extract of Adansonia digitata fruit (MEADF) pulp on N
methodsFourty eight (48) wistar rats divided into six (6) groups (eight rats each) were employed. The induction of hypertension was achieved using L-NAME (40mg//kg body weight) by oral gavages. The induced rats were treated with MEADF pulp (200 and 400 mg/kg body weight) and Ramipril (10 mg/kg) and the remaining three groups serve as control. Serum haemodynamic and biochemical modifiable parameters were determined using standard assay procedures
resultsAdministration of MEADF to the rats exerted a dose-dependent lowering effect on the elevated systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate towards the normal physiological threshold. At 400 mg/kg of MEADF, there was significant (p < 0.05) reduction in serum lipid profile and biomarkers associated with endothelial dysfunction [angiotensin converting enzyme (ACE) activity], inflammation (C-reactive protein and interleukin-1β), oxidative stress (malondialdehyde) and cardiac injury (creatine kinase-MB and lactate dehydrogenase activities). However, serum concentrations of nitric oxide, high density lipoprotein cholesterol, total bilirubin and albumin were not significantly (p < 0.05) different from those found in normal control group.
conclusionThis study therefore demonstrates that MEADF possesses an in vivo ACE inhibitory activity, hypotensive potential and the ability to avert further degeneration of biochemical and physiological upsets associated with L-NAME induced hypertension.
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