ArticleNeuroscience bulletin2021
Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment.
Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Variations in perfusion detectable in advance of microstructure in white matter aging.GeroScience · 2026Article
- Cerebral small vessel disease moderates the association between executive dysfunction and spontaneous neural activity in adults who lost their only child.BMC medical imaging · 2026Article
- Microstructural brain changes and their impact on hemorrhagic stroke recovery: a neurite orientation dispersion and density imaging-based study.Quantitative imaging in medicine and surgery · 2025Article
- Voxel-based morphometry reveals gray matter atrophy in cerebral small vessel disease: correlation with cognitive impairment.Quantitative imaging in medicine and surgery · 2025Article
- Neuroimaging and Genetic Markers of Cerebral Small Vessel Disease and Cognitive Outcomes: A Systematic Review and Meta-Analysis (NEUROGEN-SVD Study).Diagnostics (Basel, Switzerland) · 2025Article
- Cortical structural degeneration and functional network connectivity changes in patients with subcortical vascular cognitive impairment.Neuroradiology · 2025Article
- White matter hyperintensities drive propagating grey matter atrophy in cerebral small vessel disease.Brain communications · 2025Article
- Altered automatic gaze processing in older adults.Frontiers in aging neuroscience · 2025Article
- White Matter Hyperintensities and Mild TBI in Post-9/11 Veterans and Service Members.Military medicine · 2024Article
- Establishment and evaluation of a clinical prediction model for cognitive impairment in patients with cerebral small vessel disease.BMC neuroscience · 2024Article
- Identifying Leukoaraiosis with Mild Cognitive Impairment by Fusing Multiple MRI Morphological Metrics and Ensemble Machine Learning.Journal of imaging informatics in medicine · 2024Article
- Gray matter atrophy and white matter lesions burden in delayed cognitive decline following carbon monoxide poisoning.Human brain mapping · 2024Article
- Article
- Transcriptional patterns of brain structural abnormalities in CSVD-related cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease.Neuroscience bulletin · 2023Article
- Differences in Gray Matter Volume in Cerebral Small Vessel Disease Patients with and without Sleep Disturbance.Brain sciences · 2023Article
- Relationships of Residential Distance to Major Traffic Roads with Dementia Incidence and Brain Structure Measures: Mediation Role of Air Pollution.Health data science · 2023Article
- Decreased GABA levels of the anterior and posterior cingulate cortex are associated with executive dysfunction in mild cognitive impairment.Frontiers in neuroscience · 2023Article
- Serum glial fibrillary acidic protein indicates memory impairment in patients with chronic heart failure.ESC heart failure · 2022Article
- The effect of regional white matter hyperintensities on essential tremor subtypes and severity.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyperintensities (WMH) but no consensus has yet emerged. Here, we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment (WMH-MCI), 43 WMH patients without cognitive impairment, and 55 healthy controls. Both WMH groups showed GM atrophy in the bilateral thalamus, fronto-insular cortices, and several parietal-temporal regions, and the WMH-MCI group showed more extensive and severe GM atrophy. The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients. Furthermore, the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control analyses. These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.