Evidence map›Paper›PMID 33826038›Full record

Trial reportJournal of autism and developmental disorders2022

Moderators of Response to Personalized and Standard Care Cognitive-Behavioral Therapy for Youth with Autism Spectrum Disorder and Comorbid Anxiety.

Eric A Storch, Jeffrey J Wood, Andrew G Guzick, Brent J Small, Connor M Kerns, D Luis Ordaz, Sophie C Schneider, Philip C Kendall

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02028247 (2/3 Treatment of Anxiety in Autism Spectrum Disorder), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02028247 nacompletednot on this map

2/3 Treatment of Anxiety in Autism Spectrum Disorder

TypeinterventionalSponsorUniversity of South FloridaRan2014 to 2018Enrolled214ConditionsAutism Spectrum Disorders, Autism, Asperger's Syndrome, Pervasive Developmental Disability - Not Otherwise SpecifiedArmsPersonalized Cognitive-behavioral therapy, Standard Practice Cognitive-behavioral therapy, Treatment as Usual
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Implications of cooccurring ADHD for the cognitive behavioural treatment of anxiety in autistic children.Journal of child psychology and psychiatry, and allied disciplines · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eric A StorchDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1977 Butler Blvd, Suite 4-400, Houston, TX, 77030, USA. eric.storch@bcm.edu.
Jeffrey J WoodDepartment of Education, University of California, Los Angeles, CA, USA.
Andrew G GuzickDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1977 Butler Blvd, Suite 4-400, Houston, TX, 77030, USA.
Brent J SmallSchool of Aging Studies, University of South Florida, Tampa, FL, USA.
Connor M KernsDepartment of Psychology, University of British Columbia, Vancouver, BC, Canada.
D Luis OrdazJacob Center for Evidence-Based Therapy, Boca Raton, FL, USA.
Sophie C SchneiderDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1977 Butler Blvd, Suite 4-400, Houston, TX, 77030, USA.
Philip C KendallDepartment of Psychology, Temple University, Philadelphia, PA, USA.

Funding

2/3 Treatment of Anxiety in Autism Spectrum DisorderR01HD080096 · NICHD · UNIVERSITY OF SOUTH FLORIDA · PI STORCH, ERIC A. · 2014 to 2016
$471k
National Institute of Child Health and Human Development 1R01HD080096
6 · The paper itself

Abstract

Anxiety/obsessive-compulsive disorders are common among youth with autism spectrum disorder (ASD). Two versions of cognitive behavior therapy (CBT) are effective, with some advantage for a personalized, adapted version. This study evaluated predictors and moderators of standard CBT and adapted CBT. Youth (N = 167) ages 7-13 were randomized to standard or adapted CBT, or treatment-as-usual. Age, IQ, ASD severity, and emotional-behavioral symptom severity were examined. More severe internalizing and emotional-behavioral problems predicted poorer treatment outcomes especially in standard versus personalized CBT. Elevated repetitive behaviors and restricted interests predicted poorer treatment outcomes across treatments, though youth with "moderate" repetitive behaviors and restricted interested experienced poorer outcomes only in standard but not personalized CBT. Externalizing symptoms directly predicted treatment outcomes. Older age predicted improved outcomes in adapted but not standard CBT. Findings highlight the need for further treatment refinements and the value in adapting treatment for youth with more complex presentations. Trial Registration Clinicialtrials.gov: NCT02028247; https://clinicaltrials.gov/ct2/show/NCT02028247 .

Indexed as

Autism Spectrum DisorderCognitive Behavioral TherapyObsessive-Compulsive DisorderAdolescentAnxietyAnxiety DisordersChildHumansTreatment OutcomeAdolescentsASDCBTChildrenPredictorsTreatment

Identifiers

PMID33826038

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.