ArticleVirchows Archiv : an international journal of pathology2021
Localized ALK-positive histiocytosis in a Chinese woman: report of a case in the lung with a novel EML4-ALK rearrangement.
Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- ALK-Positive Histiocytosis With Unilateral Breast Involvement: A Case Report.Clinical case reports · 2026Article
- A rare case of ALK-positive histiocytosis with neurological involvement in a 70-year-old woman successfully managed with partial resection and alectinib.International cancer conference journal · 2025Article
- A case of pulmonary ALK-positive histiocytosis combined with Birt-Hogg-Dubé syndrome carrying anFrontiers in immunology · 2024Review
- Multisystem ALK-positive histiocytosis: a multi-case study and literature review.Orphanet journal of rare diseases · 2023Review
- Case report: ALK-positive histiocytosis presented as bilateral synchronous breast masses with long-term remission on crizotinib.Frontiers in medicine · 2023Article
- Failure of crizotinib based systemic treatment in ALK positive histiocytosis involving the central nervous system: a case report and literature review.BMC pediatrics · 2022Review
- Article
- Case Report: Rare Systemic and Aggressive ALK-Positive Histiocytosis With Recurrent Pancreatitis Treating byFrontiers in medicine · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
ALK-positive histiocytosis (APH) is a newly defined entity with specific histological features and a highly recurrent KIF5B-ALK gene fusion. APH is characterized by clonal proliferation of histiocytes and can present as either systemic or localized. It was first described in infants and then expanded to older children and adults. Although lung involvement has been shown in three systemic cases, localized lung lesions have not previously been reported. The ALK gene has many fusion partners in addition to KIF5B in APH. Here, we report a striking case of localized APH in the lung harboring a rare EML4-ALK rearrangement in a 52-year-old Chinese woman. Furthermore, we reviewed the previously published APH cases, analyzed the partner genes of the ALK fusions, and explored the role of patient ethnicity. We discovered a link between ethnicity and this rare disease.
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