Evidence map›Paper›PMID 33825870›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2021

Myeloarchitectonic Asymmetries of Language Regions in the Human Brain.

Di Yuan, Daiyi Luo, Veronica P Y Kwok, Yulong Zhou, Haoyue Tian, Qianqian Yu, Jie An, Jia-Hong Gao, Shijun Qiu, Li Hai Tan

Open access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Di YuanGuangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Daiyi LuoGuangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Veronica P Y KwokCenter for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518060, China.
Yulong ZhouGuangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Haoyue TianGuangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Qianqian YuCenter for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518060, China.
Jie AnDepartment of Radiology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510400, China.
Jia-Hong GaoMcGovern Institute for Brain Research, Peking University, Beijing, China.
Shijun QiuDepartment of Radiology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510400, China.
Li Hai TanGuangdong-Hongkong-Macau Institute of CNS Regeneration and Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Jinan University · CNShenzhen Institute of Neuroscience · CNFirst Affiliated Hospital of Guangzhou University of Chinese Medicine · CNPeking University · CN

Funding

Guangdong Key Basic Research 2018B030332001Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team 2016ZT06S220Shenzhen Basic Research JCYJ20170412164413575Shenzhen Peacock Team Plan KQTD2015033016104926
6 · The paper itself

Abstract

One prominent theory in neuroscience and psychology assumes that cortical regions for language are left hemisphere lateralized in the human brain. In the current study, we used a novel technique, quantitative magnetic resonance imaging (qMRI), to examine interhemispheric asymmetries in language regions in terms of macromolecular tissue volume (MTV) and quantitative longitudinal relaxation time (T1) maps in the living human brain. These two measures are known to reflect cortical myeloarchitecture from the microstructural perspective. One hundred and fifteen adults (55 male, 60 female) were examined for their myeloarchitectonic asymmetries of language regions. We found that the cortical myeloarchitecture of inferior frontal areas including the pars opercularis, pars triangularis, and pars orbitalis is left lateralized, while that of the middle temporal gyrus, Heschl's gyrus, and planum temporale is right lateralized. Moreover, the leftward lateralization of myelination structure is significantly correlated with language skills measured by phonemic and speech tone awareness. This study reveals for the first time a mixed pattern of myeloarchitectonic asymmetries, which calls for a general theory to accommodate the full complexity of principles underlying human hemispheric specialization.

Indexed as

LanguageAdultBrainBrain MappingCerebral CortexFemaleFunctional LateralityHumansLanguage TestsMagnetic Resonance ImagingMaleMyelin SheathPsychomotor PerformanceSpeechSpeech PerceptionYoung AdultasymmetrylanguagemicrostructuremyelinationqMRI

Identifiers

PMID33825870
PMCPMC8328200
OpenAlexW3144555909

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.