Evidence map›Paper›PMID 33825268›Full record

ArticleJournal of cardiovascular electrophysiology2021

Optimal substrate modification strategies using catheter ablation in patients with persistent atrial fibrillation: 3-year follow-up outcomes.

Yu-Cheng Hsieh, Yenn-Jiang Lin, Men-Tzung Lo, Yun-Yu Chen, Chin-Yu Lin, Chen Lin, Fa-Po Chung, Li-Wei Lo, Shih-Lin Chang, Tze-Fan Chao and 10 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05333952 naunknown statusnot on this map

A Randomized Controlled Study on the Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation

TypeinterventionalSponsorTaipei Veterans General Hospital, TaiwanRan2019 to 2025Enrolled80ConditionsAtrial Fibrillation, PersistentArmsPulmonary vein isolation, Substrate ablation(PRISM based)
NCT05426603 naunknown statusnot on this map

A Randomized Controlled Study on the Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation

TypeinterventionalSponsorBuddhist Tzu Chi General HospitalRan2019 to 2025Enrolled80ConditionsAtrial Fibrillation, PersistentArmsPulmonary vein isolation, Substrate ablation(PRISM based)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Optimal mitral isthmus flutter ablation by radiofrequency.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Yu-Cheng HsiehCardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.ORCID 0000-0001-6218-7139
Yenn-Jiang LinDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0001-8395-1052
Men-Tzung LoDepartment of Biomedical Sciences and Engineering, National Central University, Chungli, Taiwan.
Yun-Yu ChenDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Chin-Yu LinDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Chen LinDepartment of Biomedical Sciences and Engineering, National Central University, Chungli, Taiwan.
Fa-Po ChungDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Li-Wei LoDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0001-9102-227X
Shih-Lin ChangDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Tze-Fan ChaoDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0002-6587-3094
Yu-Feng HuDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.ORCID 0000-0001-5715-2070
Ta-Chuan TuanDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Jo-Nan LiaoDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Cheng-I WuDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Chih-Min LiuDepartment of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Jennifer-Jeanne B ViceraDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0001-6722-1826
Chun-Chao ChenDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0002-4888-3709
Chye-Gen ChinDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0001-9670-9708
Isaiah C LugtuDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0003-1635-1625
Shih-Ann ChenCardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWNational Central University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to assess the comparative efficacy of four ablation strategies on the incidence rates of freedom from atrial fibrillation (AF) or atrial tachycardia (AT) through a 3-year follow-up in patients with persistent AF.

backgroundThe optimal substrate modification strategies using catheter ablation for patients with persistent AF remain unclear.

methodsPatients with persistent AF were enrolled consecutively to undergo each of four ablation strategies: (a) Group 1 (Gp 1, n = 69), pulmonary vein isolation (PVI) plus rotor ablation assisted by similarity index and phase mapping; (b) Gp 2 (n = 75), PVI plus linear ablations at the left atrium; (c) Gp 3 (n = 42), PVI plus the elimination of complex fractionated atrial electrograms; (d) Gp 4 (n = 67), PVI only. Potential confounders were adjusted via a multivariate survival parametric model.

resultsBaseline characteristics were similar across the four groups. At a follow-up period of 34.9 ± 38.6 months, patients in Gp 1 showed the highest rate of freedom from AF compared with the other three groups (p = .002), while patients in Gp 3 and 4 showed lower rates of freedom from AT than those of the other two groups (p = .006). Independent predictors of recurrence of AF were the ablation strategy (p = .002) and left atrial diameter (LAD) (p = .01).

conclusionIn patients with persistent AF, a substrate modification strategy using rotor ablation assisted by similarity index and phase mapping provided a benefit for maintaining sinus rhythm compared with the other strategies. Both ablation strategy and baseline LAD predicted the 3-year outcomes of freedom from AT/AF.

Indexed as

Atrial FibrillationCatheter AblationPulmonary VeinsFollow-Up StudiesHumansRecurrenceTreatment Outcomeatrial tachycardiapersistent atrial fibrillationphase mappulmonary vein isolationsimilarity indexsubstrate

Identifiers

PMID33825268
PMCPMC8252615
OpenAlexW3143621938

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.