Evidence map›Paper›PMID 33825146›Full record

ReviewWorld journal of microbiology & biotechnology2021

Advances in biotechnological production of β-alanine.

Leilei Wang, Yufeng Mao, Zhiwen Wang, Hongwu Ma, Tao Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of microbiology & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Combining Electrochemical Reduction with Biosynthesis for Directed Conversion of COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. eLife · 2025
    Article
  7. Article
  8. Article
  9. The Possible Roles ofCurrent medicinal chemistry · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Study on the construction technology of β-alanine synthesizingFrontiers in bioengineering and biotechnology · 2023
    Article
  15. Advances in the synthesis of β-alanine.Frontiers in bioengineering and biotechnology · 2023
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leilei WangFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Department of Biochemical Engineering, School of Chemical Engineering and Technology, SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, People's Republic of China.
Yufeng MaoKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Zhiwen WangFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Department of Biochemical Engineering, School of Chemical Engineering and Technology, SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, People's Republic of China.
Hongwu MaKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. chentao@tju.edu.cn.
Tao ChenFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Department of Biochemical Engineering, School of Chemical Engineering and Technology, SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, People's Republic of China. chentao@tju.edu.cn.ORCID http://orcid.org/0000-0001-9588-1821

Funding

National Natural Science Foundation of China 21621004National Natural Science Foundation of China 21776208
6 · The paper itself

Abstract

β-Alanine (3-aminopropionic acid) is the only naturally occurring β-type amino acid. Although it is not incorporated into proteins, it has important physiological functions in the metabolism of animals, plants and microorganisms. Furthermore, it has attracted great interest due to its wide usage as a precursor of many significant industrial chemicals for medicine, feed, food, environmental applications and other fields. With the depletion of fossil fuels and concerns regarding environmental issues, biological production of β-alanine has attracted more attention relative to chemical methods. In this review, we first summarize the pathways through which natural microorganisms synthesize β-alanine. Then, the current research progress in the biological synthesis of β-alanine is also elaborated. Finally, we discuss the main problems and challenges in optimizing the biological pathways, offering perspectives on promising new biological approaches.

Indexed as

BiocatalysisBiotechnologyMetabolic Networks and Pathwaysbeta-AlanineEnzymesFermentationMetabolic Engineeringbeta-AlanineEnzymesBiological methodsEnzyme-catalyzed methodsFermentation methodsWhole-cell catalytic methodsβ-Alanine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.