Trial reportJournal of assisted reproduction and genetics2021
Fresh embryo transfer versus freeze-only after in vitro maturation with a pre-maturation step in women with high antral follicle count: a randomized controlled pilot study.
Trial report in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04297553 (Outcomes of Fresh Transfer Versus Freeze-only After CAPA IVM on PCOS Patients), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of Fresh Transfer Versus Freeze-only After CAPA IVM on PCOS Patients
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- FSH priming and hormonal modulation of oocyte competence inFrontiers in endocrinology · 2025Pooled it
- Use of low versus high oxygen tension during pre-maturation only in capacitation in vitro maturation (CAPA-IVM): impact on oocyte maturation and metabolism.Journal of assisted reproduction and genetics · 2026Article
- Impact of anti-Müllerian hormone on pregnancy outcomes in in vitro maturation: a retrospective cohort study.Journal of ovarian research · 2026Article
- Impacts of Oxygen Tension on Developmental Competence of Preimplantation Embryos.Biomolecules · 2026Review
- Biphasic CAPA-IVM Improves Equine Oocyte Quality and Subsequent Embryo Development Without Inducing Genetic Aberrations.International journal of molecular sciences · 2025Article
- Impact of low versus high oxygen tension on human oocyte maturation during biphasic capacitation IVM (CAPA-IVM).Journal of assisted reproduction and genetics · 2025Article
- Current status and hotspots of in vitro oocyte maturation: a bibliometric study of the past two decades.Journal of assisted reproduction and genetics · 2025Review
- Minimising OHSS in women with PCOS.Frontiers in endocrinology · 2025Review
- In vitro maturation (IVM) of human immature oocytes: is it still relevant?Reproductive biology and endocrinology : RB&E · 2023Review
- Cumulative live birth rate after oocyte in vitro maturation with a pre-maturation step in women with polycystic ovary syndrome or high antral follicle count.Journal of assisted reproduction and genetics · 2023Article
- Frozen embryo transfer in the menstrual cycle after moderate-severe ovarian hyperstimulation syndrome: a retrospective analysis.BMC pregnancy and childbirth · 2022Article
- Natural cycles achieve better pregnancy outcomes than artificial cycles in non-PCOS women undergoing vitrified single-blastocyst transfer: a retrospective cohort study of 6840 cycles.Journal of assisted reproduction and genetics · 2022Article
- Perspectives on the development and future of oocyte IVM in clinical practice.Journal of assisted reproduction and genetics · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeIn vitro maturation (IVM) is an alternative to in vitro fertilization (IVF) for women at high risk of developing ovarian hyperstimulation syndrome (OHSS). This study determined the effectiveness and safety of a freeze-only strategy versus fresh embryo transfer (ET) after IVM with a pre-maturation step (CAPA-IVM) in women with a high antral follicle count (AFC).
methodsThis randomized, controlled pilot study (NCT04297553) was conducted between March and November 2020. Forty women aged 18-37 years with a high AFC (≥24 follicles in both ovaries) undergoing one cycle of CAPA-IVM were randomized to a freeze-only strategy with subsequent frozen ET (n = 20) or to fresh ET (n = 20). The primary endpoint was ongoing pregnancy resulting in live birth after the first ET of the started treatment cycle.
resultsThe ongoing pregnancy rate in the freeze-only group (65%) was significantly higher than that in the fresh ET group (25%; p = 0.03), as was the live birth rate (60% versus 20%; p = 0.02). Clinical pregnancy rate was numerically, but not significantly, higher after frozen versus fresh ET (70% versus 35%; p = 0.06), while the number of day 3 or good quality embryos, endometrial thickness on the day of oocyte pick-up, implantation rate, and positive pregnancy test rate did not differ significantly between groups. No cases of OHSS were observed, and miscarriage and multiple pregnancy rates were similar in the two groups.
conclusionsThese findings suggest that the effectiveness of CAPA-IVM could be improved considerably by using a freeze-only strategy followed by frozen ET in subsequent cycles. TRIAL REGISTRATION NUMBER: NCT04297553 ( www.clinicaltrials.gov ).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.