Trial reportWorld journal of surgery2021
Validation of the Appendicitis Inflammatory Response (AIR) Score.
Trial report in World journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00971438 (Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children.BJS open · 2025Guideline
- Diagnostic value of the appendicitis inflammatory response (AIR) score. A systematic review and meta-analysis.World journal of emergency surgery : WJES · 2025Pooled it
- A Century of Post-Traumatic Appendicitis: A Comprehensive Review with an Illustrative Case.Pediatric reports · 2026Article
- Appendicitis inflammatory response versus pediatric appendicitis score for grading disease severity in children.Scientific reports · 2026Observational
- Assessment of Acute Appendicitis in Pregnant Women: A Systematic Review of Current Evidence.Cureus · 2026Review
- Appendicitis.Nature reviews. Disease primers · 2025Review
- Acute appendicitis in patients suffering from Immunocompromising hematologic malignancies or chemotherapy-related leukopenia: a cohort study.BMC cancer · 2025Article
- The Role of Hyponatremia in Identifying Complicated Cases of Acute Appendicitis in the Pediatric Population.Diagnostics (Basel, Switzerland) · 2025Article
- Risk prediction and effect evaluation of complicated appendicitis based on XGBoost modeling.BMC gastroenterology · 2025Article
- Evidence-based, cost-effective management of acute appendicitis: An algorithm of the Journal of Trauma and Acute Care Surgery emergency general surgery algorithms work group.The journal of trauma and acute care surgery · 2025Article
- The EUPEMEN (EUropean PErioperative MEdical Networking) Protocol for Acute Appendicitis: Recommendations for Perioperative Care.Journal of clinical medicine · 2024Article
- Diagnostic Value of Serum Sodium Level and Neutrophil-to-Lymphocyte Ratio in Predicting Severity of Acute Appendicitis: A Retrospective Cross-Sectional Two-Center Study.Medicina (Kaunas, Lithuania) · 2024Article
- Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis.World journal of gastrointestinal surgery · 2024Article
- Predicting complicated appendicitis is possible without the use of sectional imaging-presenting the NoCtApp score.International journal of colorectal disease · 2023Article
- Applicability of American College of Radiology Appropriateness Criteria Decision-Making Model for Acute Appendicitis Diagnosis in Children.Diagnostics (Basel, Switzerland) · 2022Article
- Factors Influencing the Difficulty and Need for External Help during Laparoscopic Appendectomy: Analysis of 485 Procedures from the Resident-1 Multicentre Trial.Journal of personalized medicine · 2022Article
- IL-6 Serum Levels Can Enhance the Diagnostic Power of Standard Blood Tests for Acute Appendicitis.Children (Basel, Switzerland) · 2022Article
- The Diagnostic Differentiation Challenge in Acute Appendicitis: How to Distinguish between Uncomplicated and Complicated Appendicitis in Adults.Diagnostics (Basel, Switzerland) · 2022Review
- Article
- Utility of Red Cell Distribution Width (RDW) as a Noninvasive Biomarker for the Diagnosis of Acute Appendicitis: A Systematic Review and Meta-Analysis of 5222 Cases.Diagnostics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with suspicion of appendicitis present with a wide range of severity. Score-based risk stratification can optimise the management of these patients. This prospective study validates the Appendicitis Inflammatory Response (AIR) score in patients with suspicion of appendicitis.
methodConsecutive patients over the age of five with suspicion of appendicitis presenting at 25 Swedish hospital's emergency departments were prospectively included. The diagnostic properties of the AIR score are estimated.
resultsSome 3878 patients were included, 821 with uncomplicated and 724 with complicated appendicitis, 1986 with non-specific abdominal pain and 347 with other diagnoses. The score performed better in detecting complicated appendicitis (ROC area 0.89 (95% confidence interval (CI) 0.88-0.90) versus 0.83 (CI 0.82-0.84) for any appendicitis, p < 0.001), in patients below age 15 years and in patients with >47 h duration of symptoms (ROC area 0.93, CI 0.90-0.95 for complicated and 0.87, CI 0.84-0.90 for any appendicitis in both categories). Complicated appendicitis is unlikely at AIR score <4 points (Negative Predictive Value 99%, CI 98-100%). Appendicitis is likely at AIR score >8 points, especially in young patients (positive predictive value (PPV) 96%, CI 90-100%) and men (PPV 89%, CI 84-93%).
conclusionsThe AIR score has high sensitivity for complicated appendicitis and identifies subgroups with low probability of complicated appendicitis or high probability of appendicitis. The discriminating capacity is high in children and patients with long duration of symptoms. It performs equally well in both sexes. This verifies the AIR score as a valid decision support. Trial registration number https://clinicaltrials.gov/ct2/show/NCT00971438.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.