ArticleG3 (Bethesda, Md.)2021
Diploid chromosome-scale assembly of the Muscadinia rotundifolia genome supports chromosome fusion and disease resistance gene expansion during Vitis and Muscadinia divergence.
Article in G3 (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 54 citations in OpenAlex.
- Haplotype graph analysis of PdR1 uncovers resistance diversity to Pierce's disease in Vitis arizonica and its hybrids.G3 (Bethesda, Md.) · 2026Article
- An advanced genotyping tool to inspect grapevine variability: the AxiomFrontiers in plant science · 2026Article
- Dissection of the Ren6 and Ren7 powdery mildew resistance loci in Vitis piasezkii DVIT2027 using phased parental-progeny genomes and intraspecific locus graph reconstruction.G3 (Bethesda, Md.) · 2025Article
- Advances in grape and pathogen genomics toward durable grapevine disease resistance.Journal of experimental botany · 2025Review
- Evolutionary conservation of the grape sex-determining region in angiosperms and emergence of dioecy in Vitaceae.Nature communications · 2025Article
- The genome ofHorticulture research · 2025Article
- A divergent haplotype with a large deletion at the berry color locus causes a white-skinned phenotype in grapevine.Horticulture research · 2025Article
- Super pangenome of Vitis empowers identification of downy mildew resistance genes for grapevine improvement.Nature genetics · 2025Article
- The assembly and annotation of two teinturier grapevine varieties, Dakapo and Rubired.GigaByte (Hong Kong, China) · 2025Article
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- Population comparative genomics discovers gene gain and loss during grapevine domestication.Plant physiology · 2024Article
- Diploid genome assembly of the Malbec grapevine cultivar enables haplotype-aware analysis of transcriptomic differences underlying clonal phenotypic variation.Horticulture research · 2024Article
- A super-pangenome of the North American wild grape species.Genome biology · 2023Article
- Long-read, chromosome-scale assembly of Vitis rotundifolia cv. Carlos and its unique resistance to Xylella fastidiosa subsp. fastidiosa.BMC genomics · 2023Article
- The complete reference genome for grapevine (Horticulture research · 2023Article
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- Chromosome-scale genomics, metabolomics, and transcriptomics provide insight into the synthesis and regulation of phenols inFrontiers in plant science · 2023Article
- Development of a High-Density Genetic Map for Muscadine Grape Using a Mapping Population from Selfing of the Perfect-Flowered Vine 'Dixie'.Plants (Basel, Switzerland) · 2022Article
- HiFi chromosome-scale diploid assemblies of the grape rootstocks 110R, Kober 5BB, and 101-14 Mgt.Scientific data · 2022Article
- A recessive mutation in muscadine grapes causes berry color-loss without influencing anthocyanin pathway.Communications biology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscadinia rotundifolia, the muscadine grape, has been cultivated for centuries in the southeastern United States. M. rotundifolia is resistant to many of the pathogens that detrimentally affect Vitis vinifera, the grape species commonly used for winemaking. For this reason, M. rotundifolia is a valuable genetic resource for breeding. Single-molecule real-time reads were combined with optical maps to reconstruct the two haplotypes of each of the 20 M. rotundifolia cv. Trayshed chromosomes. The completeness and accuracy of the assembly were confirmed using a high-density linkage map. Protein-coding genes were annotated using an integrated and comprehensive approach. This included using full-length cDNA sequencing (Iso-Seq) to improve gene structure and hypothetical spliced variant predictions. Our data strongly support that Muscadinia chromosomes 7 and 20 are fused in Vitis and pinpoint the location of the fusion in Cabernet Sauvignon and PN40024 chromosome 7. Disease-related gene numbers in Trayshed and Cabernet Sauvignon were similar, but their clustering locations were different. A dramatic expansion of the Toll/Interleukin-1 Receptor-like Nucleotide-Binding Site Leucine-Rich Repeat (TIR-NBS-LRR) class was detected on Trayshed chromosome 12 at the Resistance to Uncinula necator 1 (RUN1)/Resistance to Plasmopara viticola 1 (RPV1) locus, which confers strong dominant resistance to powdery and downy mildews. A genome browser, annotation, and Blast tool for Trayshed are available at www.grapegenomics.com.
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