Evidence map›Paper›PMID 33824853›Full record

ArticleAfrican journal of laboratory medicine2021

Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression.

Jude O Okoye, Anthony A Ngokere, Charles C Onyenekwe, Olaposi Omotuyi, Deborah I Dada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jude O OkoyeDepartment of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria.ORCID https://orcid.org/0000-0002-7194-5592
Anthony A NgokereDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra, Nigeria.ORCID https://orcid.org/0000-0001-9113-4802
Charles C OnyenekweDepartment of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra, Nigeria.ORCID https://orcid.org/0000-0002-7011-4797
Olaposi OmotuyiDepartment of Biochemistry, Centre for Biotechnology, Adekunle Ajasin University, Akungba-Akoko, Ondo, Nigeria.ORCID https://orcid.org/0000-0002-5473-745X
Deborah I DadaDepartment of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria.ORCID https://orcid.org/0000-0003-3389-0145

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.

Indexed as

epithelial-mesenchymal transitionEpstein-Barr virusherpes simplex virus 2human papilloma virusmicroRNAs

Identifiers

PMID33824853
PMCPMC8008003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.