Evidence map›Paper›PMID 33824735›Full record

ArticleSouthern African journal of HIV medicine2021

Ocular manifestations of people living with HIV in Tunisia.

Dorsaf Saadouli, Lamia Ammari, Khaoula Ben Mansour, Yosra Yahyaoui, Sameh Aissa, El Afrit Mohamed Ali, Salem Yahyaoui, Hanene Tiouri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Southern African journal of HIV medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Incidence and Risk Factors of Bilateral Herpetic Keratitis: 2022 Update.Tropical medicine and infectious disease · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dorsaf SaadouliDepartment of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0001-8927-5008
Lamia AmmariDepartment of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID 0000-0003-1952-0164
Khaoula Ben MansourDepartment of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0003-3548-6031
Yosra YahyaouiFaculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-8707-4613
Sameh AissaDepartment of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-5733-404X
El Afrit Mohamed AliDepartment of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0002-2045-1699
Salem YahyaouiFaculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0001-9015-5521
Hanene TiouriDepartment of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID https://orcid.org/0000-0003-2210-2086
Faculté de médecine de TunisTunis El Manar University · TNTunis University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOcular involvement is a common complication of human immunodeficiency virus (HIV). Knowledge about this topic in Tunisia is limited.

objectiveTo investigate ophthalmic manifestations in patients living with HIV in Tunisia.

methodThis was an observational study, performed between January 2007 and December 2016. We included patients with ocular disorders related to HIV. The data were recorded retrospectively from chart review.

resultsAmongst 98 people living with HIV (PLWH), 36 participants (55 eyes) had ocular manifestations. The mean age was 32.2 ± 5.6 years. Twenty-four patients were men and 12 were women. The mean value of CD4+ T-cell count was 156.5 ± 4.2 cells/µL. Bilateral lesions were found in 19 eyes. Best corrected visual acuity was better than 6/12 in 36 eyes. The most common ocular finding was dry eye syndrome (22%), cotton-wool spots (20%) and retinal haemorrhage (16%) followed by cytomegalovirus (CMV) retinitis (9%), anterior uveitis (7%), toxoplasmosis (4%) and tuberculosis retinochoroiditis (7%) Herpetic keratitis (5%), Herpes zoster ophthalmicus (2%) and syphilitic chorioretinitis (2%). Papilledema was found in three eyes (5%). Panuveitis was observed in four eyes (7%): three of them were associated with chorioretinal toxoplasmosis, syphilitic chorioretinitis and CMV retinitis. The fourth was attributable to immune recovery uveitis. A CD4+ T-cell count of ≤ 200 cells/µL was found to be an independent risk factor for developing posterior segment manifestations.

conclusionVarious ophthalmic manifestations were observed in PLWH. The most common lesion was retinopathy. Ocular involvement can be serious leading to poor visual prognosis, which requires close collaboration between the ophthalmologist and infectious disease physician.

Indexed as

acquired immunodeficiency syndromecytomegalovirus retinitishuman immunodeficiency virusimmune recovery uveitisocular manifestationuveitis

Identifiers

PMID33824735
PMCPMC8008002
OpenAlexW3137144980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.