Evidence map›Paper›PMID 33824664›Full record

ArticleInternational journal of otolaryngology2021

Does HPV Subtype Predict Outcomes in Head and Neck Cancers?

Hedyeh Ziai, Andrew Warner, Neil Mundi, Krupal Patel, Eun Jae Chung, Christopher J Howlett, Paul Plantinga, John Yoo, S Danielle MacNeil, Kevin Fung and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Hedyeh ZiaiDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
Andrew WarnerDepartment of Oncology, Western University, ON, Canada.
Neil MundiDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
Krupal PatelDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
Eun Jae ChungDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
Christopher J HowlettDepartment of Pathology, Western University, ON, Canada.
Paul PlantingaDepartment of Pathology, Western University, ON, Canada.
John YooDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
S Danielle MacNeilDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
Kevin FungDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
Joe S MymrykDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
John W BarrettDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.
David A PalmaDepartment of Oncology, Western University, ON, Canada.
Anthony C NicholsDepartment of Otolaryngology-Head and Neck Surgery, Western University, ON, Canada.ORCID https://orcid.org/0000-0002-0760-980X
Western University · CAUniversity of Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, reanalysis of The Cancer Genome Atlas study demonstrated that human papillomavirus (HPV) genotypes in head and neck cancers other than HPV-16 have inferior survival to HPV-16-positive tumors. We aimed to examine the association of HPV subtypes and survival in a large cohort of patient samples from our institution.

methodsFresh frozen primary site biopsy samples were collected either in clinic or at the time of surgery. Patient demographic, staging, and survival data were also collected. Tumors were tested for HPV subtypes by quantitative polymerase chain reaction (qPCR). Univariable and multivariable analyses were performed using Cox proportional hazards regression.

results280 patient biopsy samples were collected between 2011 and 2017. Mean ± standard deviation (SD) age was 61.9 ± 11.1 years and most patients (78%) were male. The majority of cancers were of the oral cavity (60%) or oropharynx (25%) and 30% had HPV-positive disease. Median follow-up was 3.76 years and 96/280 patients (34%) developed recurrences. Patients with p16-positive versus negative disease had significantly improved 5-year overall survival (OS, 77.6% vs. 53.3%;

conclusionsIn contrast to the data derived from The Cancer Genome Atlas, patients with HPV-16 tumors trended towards decreased PFS and OS compared with tumors driven by other HPV genotypes. Further larger multi-institutional studies are necessary to understand the relationship between other HPV genotypes and survival in head and neck squamous cell carcinomas.

Identifiers

PMID33824664
PMCPMC8006754
OpenAlexW3126343107

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.