ArticleInternational journal of dentistry2021
Remineralization Potential of Nanohydroxyapatite Toothpaste Compared with Tricalcium Phosphate and Fluoride Toothpaste on Artificial Carious Lesions.
Article in International journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of nanohydroxyapatite paste after different pretreatment techniques on remineralization and color change of white spot lesions in children: a randomized control study.BMC oral health · 2026Trial
- Effect of remineralization after in office followed by home treatment of white spot lesions in children randomized controlled trial.Scientific reports · 2025Trial
- Comparative Evaluation of the Remineralization Potential of Fluoride-Free Bioactive Toners and Fluoride-Containing Functionalized Tricalcium Phosphate Toothpaste on the Artificially Demineralized Enamel: An In Vitro Study.European journal of dentistry · 2026Article
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Evaluating the combined effect of a biomimetic organic matrix and bioinspired fluorapatite nanoparticles on initial caries lesions.RSC advances · 2026Article
- Remineralization of early caries lesions by calcium hypophosphite in vitro: a surface microhardness study.BDJ open · 2026Article
- The Journey of Oral Hygiene: The Past, the Present, the Future.Journal of periodontal research · 2026Article
- Assessment of the remineralizing potential of nano-bioactive glass, nano-hydroxyapatite, and sodium fluoride on artificial carious lesions in primary teeth.BMC oral health · 2026Article
- A Qualitative In Vitro SEM Study on the Protective Effects of a Self-Antibacterial Nano-Hydroxyapatite Toothpaste Against Acid-Induced Enamel Surface Erosion.International journal of molecular sciences · 2026Article
- Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes.The Saudi dental journal · 2026Article
- Article
- The Effect of Home Bleaching Gel with Chitosan on Tooth Color and Mineral Alteration.Gels (Basel, Switzerland) · 2025Article
- Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges.Tissue engineering and regenerative medicine · 2025Review
- The impact of fluorinated graphene versus nanohydroxyapatite crystals on artificial white spot lesion microhardness and color change.BMC oral health · 2025Article
- Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions.Bioengineering (Basel, Switzerland) · 2025Review
- Advancements in nanohydroxyapatite: synthesis, biomedical applications and composite developments.Regenerative biomaterials · 2025Review
- Effect of a 1.1% NaF toothpaste containing Sr/F-doped bioactive glass on irradiated demineralized dentin: an in vitro study.BMC oral health · 2024Article
- Nano-Hydroxyapatite toothpaste of rice field snail shell combined with basil leaf extract as a remineralizing and antibacterial agent to prevent dental caries.Journal of clinical and experimental dentistry · 2024Article
- A Modern Multidisciplinary Method to Characterize Natural White Spot Lesions with 2D and 3D Assessments: A Preliminary Study.Journal of personalized medicine · 2024Article
- Effect of the β-tricalcium phosphate particle on dental enamel associated with 10% carbamide peroxide bleaching.Journal of clinical and experimental dentistry · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNanohydroxyapatite (nano-HA) has been utilized as an alternative agent for dental enamel remineralization. This study compared remineralization potential of nano-HA toothpaste (NHT), functionalized tricalcium phosphate toothpaste (TCPT), and fluoride toothpaste (FT) on carious lesions. MATERIALS AND
methodsSixty extracted human premolars were prepared for artificial carious lesions with synthetic polymer gel. Samples were divided into four groups according to testing agents: NHT, TCPT, FT, and one group with no treatment (NT). Each group was subjected to pH-cycling with the application of toothpaste in slurry form twice a day (2-min each) for 10 days. Surface microhardness was measured before demineralization, after demineralization, and after pH-cycling. Hardness at different periods, percentage of hardness recovery (% HR), and percentage of remineralization potential (%RP) were determined and statistically analyzed with ANOVA and Tukey comparisons (
resultsSignificant remineralization of carious lesions was observed among different toothpastes compared to NT (
conclusionsNHT has comparable capability to TCPT and FT in hardness recovery. However, decrease in carious depth was evidenced with PLM for NHT more than TCPT and FT. Thus, NHT was suggested as a potential remineralization product for treating initial carious lesions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.