Evidence map›Paper›PMID 33824611›Full record

ArticleEye and brain2021

Electrophysiological Study of Visual Pathways in Nevoid Basal Cell Carcinoma Syndrome Patients.

Antonietta Moramarco, Ludovico Alisi, Alessandro Lambiase, Sandra Giustini, Luca Lucchino, Emanuele Miraglia, Vincenzo Roberti, Marcella Nebbioso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye and brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Antonietta Moramarco *Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, Rome, 00161, Italy.
Ludovico Alisi *Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, Rome, 00161, Italy.ORCID 0000-0001-5366-882X
Alessandro LambiaseDepartment of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, Rome, 00161, Italy.ORCID 0000-0002-8974-991X
Sandra GiustiniDepartment of Dermatology, Sapienza University of Rome, Rome, 00185, Italy.ORCID 0000-0001-7034-3816
Luca LucchinoDepartment of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, Rome, 00161, Italy.
Emanuele MiragliaDepartment of Dermatology, Sapienza University of Rome, Rome, 00185, Italy.
Vincenzo RobertiDepartment of Dermatology, Sapienza University of Rome, Rome, 00185, Italy.ORCID 0000-0002-8005-1769
Marcella NebbiosoDepartment of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, Rome, 00161, Italy.ORCID 0000-0002-5512-0849
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGorlin-Goltz syndrome (GGS) also known as nevoid basal cell carcinoma syndrome (NBCCS) is a complex rare genetic disorder characterized by a wide range of clinical and radiological manifestations. Ophthalmological alterations have always been reported, but no study on the eventual pattern visual evoked potentials (pVEPs) abnormalities has yet been published. PURPOSE: The purpose of the study was to evaluate the functionality of the optic pathways in a group of NBCCS patients through pattern reversal VEPs, after a thorough exclusion of subjects with preexisting ocular and optic pathways pathologies.

methodsNineteen NBCCS patients (31 eyes) and 20 healthy controls (40 eyes) have been recruited for this study. All subjects underwent an evaluation of the functionality of the optic pathways through pVEPs with small (120'), medium (60'), and large (15') check size stimulation.

resultsNBCCS patients showed a statistically significant alteration in the transmission of the macular pathway function when compared to controls. PVEPs analysis confirmed a reduced amplitude and an increased latency of the P100 component, suggesting an involvement of the visual pathway even in the absence of ocular clinical manifestations.

conclusionVisual pathways may have been affected both by a subclinical myelination deficit, determined directly by the genetic alteration, as well as by neurological abnormalities typical of this syndrome. Further studies are warranted.

Indexed as

electrophysiologygenodermatosisGorlin-Goltz syndromenevoid basal cell carcinoma syndromePATCH1pattern visual evoked potentialsrare diseasesvisual pathway

Identifiers

PMID33824611
PMCPMC8018356
OpenAlexW3151457522

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