Evidence map›Paper›PMID 33824443›Full record

SynthesisPediatric research2022

Association of blood pressure, obesity and physical activity with arterial stiffness in children: a systematic review and meta-analysis.

Giulia Lona, Christoph Hauser, Sabrina Köchli, Denis Infanger, Katharina Endes, Arno Schmidt-Trucksäss, Henner Hanssen

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  8. A prospective analysis to assess the multifactorial risk of childhood-onset hypertension: the ExAMIN Youth SA study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Giulia Lona *Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Christoph Hauser *Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Sabrina KöchliDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Denis InfangerDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Katharina EndesDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Arno Schmidt-TrucksässDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Henner HanssenDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland. henner.hanssen@unibas.ch.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central pulse wave velocity (cPWV) is a biomarker for cardiovascular (CV) risk and a predictor for CV events in adulthood. Alterations of arterial stiffness have also been associated with CV risk in childhood. The study aimed to systematically review and meta-analyze the association of blood pressure (BP), body mass index (BMI), and cardiorespiratory fitness (CRF) with cPWV in children. Literature search was through the databases PubMed, Web of Science, Embase and the Cochrane Register of Controlled Trials. Twenty-two articles were included in the systematic review and eight articles in the meta-analysis. Higher systolic and diastolic BP were associated with higher cPWV (pooled estimated effect size (ES) 0.02 (95% CI: 0.012-0.027; P < 0.001), and ES 0.02 (95% CI: 0.011-0.029; P < 0.001); respectively). Higher BMI correlated with higher cPWV (ES 0.025 (95% CI: 0.013-0.038; P < 0.001)). CRF was inversely associated with cPWV (ES -0.033 (95% CI: -0.055 to -0.011; P = 0.002)). In children, higher BP and BMI are already related to increased cPWV, and enhanced CRF may be a preventive strategy to counteract development of CV disease later in life. IMPACT: This meta-analysis suggests that elevated blood pressure and body mass index in childhood correlate with increased central pulse wave velocity. Children with higher cardiorespiratory fitness appear to have favorably lower arterial stiffening. Elevated blood pressure and altered arterial stiffness originate early in life and childhood risk stratification as well as timely initiation of exercise treatment may help counteract development of manifest cardiovascular disease later in life.

Indexed as

Cardiovascular DiseasesHypertensionVascular StiffnessAdultBlood PressureChildExerciseHumansObesityPulse Wave Analysis

Identifiers

PMID33824443
OpenAlexW3143681854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.