ArticleMolecular psychiatry2021
Re-examining the link between childhood maltreatment and substance use disorder: a prospective, genetically informative study.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Subjective and objective experiences of childhood adversity: a meta-analysis of their agreement and relationships with psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2023Pooled it
- Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies.The American journal of psychiatry · 2023Pooled it
- Violent and sexual victimisation and incident anxiety, mood and substance use disorders in childhood and adolescence: a co-sibling study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder.Neurobiology of stress · 2026Article
- Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers.Psychopharmacology · 2026Article
- Peripheral inflammation mediates the relationship between early life stress and alcohol use.Psychopharmacology · 2026Article
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- Research Review: What we have learned about the endocannabinoid system in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Prefrontal correlates of fear generalization during endocannabinoid depletion.The Journal of clinical investigation · 2025Article
- Self-discontinuity in behavioral addictions: A psychodynamic framework.Addictive behaviors reports · 2025Review
- A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Patterns of childhood maltreatment and maternal substance use disorder on the development of emerging adult offspring substance use.Developmental psychology · 2025Article
- Childhood abuse and craving in methamphetamine-dependent individuals: the mediating role of alexithymia.European archives of psychiatry and clinical neuroscience · 2025Article
- Paternal intelligence affects school grades in children with and without ADHD - a register-based study.European child & adolescent psychiatry · 2025Article
- A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective.The American journal of drug and alcohol abuse · 2025Review
- Does sex moderate the effects of early life stress on peripheral inflammation in alcohol use disorder? A preliminary investigation.Drug and alcohol dependence · 2024Article
- Opioid drug seeking after early-life adversity: a role for delta opioid receptors.Addiction neuroscience · 2024Article
- Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The relative effects of parental alcohol use disorder and maltreatment on offspring alcohol use: Unique pathways of risk.Development and psychopathology · 2024Article
- Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence.Nature human behaviour · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood maltreatment is considered a risk factor for substance use disorders (SUD), but this is largely based on retrospective self-reports that are subject to recall bias, designs that do not control for familial confounding, or both. The specific contribution of childhood maltreatment to SUD risk thus remains unclear. Here, we evaluated this contribution in a prospective cohort with objectively recorded childhood maltreatment, using a design that allows controlling for familial confounding. We used medical records and registers to study 525 young adults (20-37 years) with prospectively and objectively documented severe maltreatment exposure, 1979 clinical controls (unexposed former child and adolescent psychiatry patients), 1388 matched healthy controls; and their siblings and cousins. We examined the association between maltreatment and SUD using Cox regression models in the population, as well as stratified within siblings in the same family. SUD risk was significantly increased with childhood maltreatment exposure (crude HR: 6.61, 95% CI: 5.81-7.53; HR adjusted for sex, birthyear, externalizing problems, parents' SUD and socioeconomic factors: 3.50, 95% CI 2.95, 4.16). An approximately threefold elevated SUD risk remained when comparing exposed individuals with their unexposed siblings (adjusted HR: 3.12, 95% CI 2.21, 4.42). We provide estimates of the association between childhood maltreatment and SUD accounting for possible confounds of both recall bias and familial factors. When familial confounding is controlled for, SUD risk attributable to severe childhood maltreatment is decreased, but nevertheless considerable. These findings establish a specific contribution of childhood maltreatment to SUD, underscoring the need for SUD prevention in young people exposed to maltreatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.