ArticleJournal of exposure science & environmental epidemiology2022
Joint effects of prenatal exposure to per- and poly-fluoroalkyl substances and psychosocial stressors on corticotropin-releasing hormone during pregnancy.
Article in Journal of exposure science & environmental epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-analysis of Chemical Exposures and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Per- and polyfluoroalkyl substances, perceived stress, and miscarriage risk in a cohort of US Black women.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Maternal mycoestrogen exposure in relation to timing of birth and placental corticotropin releasing hormone concentrations in a U.S. pregnancy cohort.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- A prospective study of per- and polyfluoroalkyl substances (PFAS), stress, and birth size in a cohort of U.S. Black women.Environmental health : a global access science source · 2026Article
- Environmental Chemicals and Maternal Depression During and After Pregnancy: a Scoping Review.Current environmental health reports · 2026Article
- Gestational PFAS concentrations in association with maternal depression and perceived stress during pregnancy and postpartum in the ECHO cohort.Environmental research · 2025Article
- Maternal exposure to trace elements and perfluoroalkyl acids and their associations with alterations of the hypothalamic-pituitary-adrenal axis.Environmental research · 2025Article
- Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- PFAS Exposure, Mental Health, and Environmental Justice in the United States: Impacts on Marginalized Communities.International journal of environmental research and public health · 2025Review
- Association of social and environmental exposures at the neighborhood level with child brain volume.Environment international · 2025Article
- A prospective cohort study of persistent endocrine-disrupting chemicals and perceived stress.American journal of epidemiology · 2024Article
- The hormonal control of parturition.Physiological reviews · 2024Review
- Per- and polyfluoroalkyl substances (PFAS), perceived stress, and depressive symptoms in a prospective cohort study of black women.The Science of the total environment · 2024Article
- Reproductive and Social Policies, Sociopolitical Stress, and Implications for Maternal and Child Health Equity.Current environmental health reports · 2024Review
- Investigation of the Link between Per- and Polyfluoroalkyl Substances and Stress Biomarkers in Bottlenose Dolphins (Environmental science & technology · 2024Article
- Review
- Perfluorooctanoic acid induces transcriptomic alterations in second trimester human cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Article
- Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study.Environmental health perspectives · 2023Article
- Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy.Molecular and cellular endocrinology · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPrenatal exposure to per- and poly-fluoroalkyl substances (PFAS) and psychosocial stressors has been associated with adverse pregnancy outcomes, including preterm birth. Previous studies have suggested that joint exposure to environmental chemical and social stressors may be contributing to disparities observed in preterm birth. Elevated corticotropin-releasing hormone (CRH) during mid-gestation may represent one biologic mechanism linking chemical and nonchemical stress exposures to preterm birth.
methodsUsing data from a prospective birth cohort (N = 497), we examined the cross-sectional associations between five individual PFAS (ng/mL; PFNA, PFOA, PFOS, PFHxS, and Me-PFOSA-AcOH) and CRH (pg/mL) using linear regression. PFAS and CRH were measured during the second trimester in serum and plasma, respectively. Coefficients were standardized to reflect change in CRH associated with an interquartile range (IQR) increase in natural log-transformed PFAS. We additionally examined if the relationship between PFAS and CRH was modified by psychosocial stress using stratified models. Self-reported depression, stressful life events, perceived stress, food insecurity, and financial strain were assessed using validated questionnaires during the second trimester and included as binary indicators of psychosocial stress.
resultsAn IQR increase in PFNA was associated with elevated CRH (β = 5.17, 95% confidence interval [CI] = 1.79, 8.55). Increased concentrations of PFOA were also moderately associated with CRH (β = 3.62, 95% CI = -0.42, 7.66). The relationship between PFNA and CRH was stronger among women who experienced stressful life events, depression, food insecurity, and financial strain compared to women who did not experience these stressors.
conclusionsThis cross-sectional study is the first to examine the relationship between PFAS exposure and CRH levels in mid-gestation. We found that these associations were stronger among women who experienced stress, which aligns with previous findings that chemical and nonchemical stressor exposures can have joint effects on health outcomes.
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