ArticleScientific reports2021
Depressive symptoms, anxiety, and quality of life of Japanese women at initiation of ART treatment.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06026553 (A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac (Toradol) at Oocyte Retrieval
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Prevalence of psychological problems among individuals and couples during assisted reproductive technology(ART) treatment: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Effects ofFrontiers in reproductive health · 2025Pooled it
- Global prevalence of major depressive disorder, generalized anxiety, stress, and depression among infertile women: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Fertility Problem Inventory: Psychometric Properties and Validation in Spanish Women Undergoing Assisted Reproduction Treatment.Journal of clinical psychology in medical settings · 2026Article
- Association between depression symptoms at the early stage of ART treatment and the likelihood of becoming pregnant: a prospective cohort study.BMC pregnancy and childbirth · 2025Article
- A mixed-methods study on negative psychological states of infertile women undergoing assisted reproductive treatment.Scientific reports · 2025Article
- Dreaming of motherhood: experiences of women who have undergone fertility treatment.Investigacion y educacion en enfermeria · 2025Article
- Article
- Japanese Health Insurance Coverage of Fertility Treatment in 2022: Does Coverage Change Patient Perspectives?Cureus · 2024Article
- Associations between Stigma, Cognitive Appraisals, Coping Strategies and Stress Responses among Japanese Women Undergoing Infertility Treatment.Healthcare (Basel, Switzerland) · 2022Article
- Association between Stigma and Anxiety, Depression, and Psychological Distress among Japanese Women Undergoing Infertility Treatment.Healthcare (Basel, Switzerland) · 2022Article
- Effects of sex, age, choice of surgical orthodontic treatment, and skeletal pattern on the psychological assessments of orthodontic patients.Scientific reports · 2022Article
- Development of the Japanese Version of the Infertility Stigma Scale: Examination of Its Reliability and Validity.Healthcare (Basel, Switzerland) · 2022Article
- Expansion of the role of midwives in gender equity and sexual/reproductive health issues in Japan.Korean journal of women health nursing · 2021Article
- Assisted reproductive technology in Japan: A summary report for 2021 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology.Reproductive medicine and biologyArticle
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assisted reproductive technology (ART) treatment accounted for 6% of total births in 2017 and is increasing which places Japan among the top worldwide in number of treatments performed. Although ART treatment patients often experience heavy physical and psychological burden, few epidemiologic studies have been conducted in Japan. We examined mental health and health-related quality of life (QOL) among women at early stages of treatment. We recruited 513 women who have initiated ART treatment, either in-vitro fertilization or intracytoplasmic sperm injection, from four medical facilities in the Tokyo area and through web-based approaches. At baseline, we collected socio-demographic information and assessed depressive symptoms, anxiety, and QOL. Descriptive analyses were performed overall and stratified by factors such as age. Mild depressive symptoms or worse, assessed with Quick Inventory of Depressive Symptoms, were observed among 54% of participants. Mean score for State-Trait Anxiety Inventory was 52 with a standard deviation of 11 for the state, and 39% were categorized as high anxiety. QOL results, assessed with SF-12, showed the same negative tendency for social functioning and role (emotional), while general health and physical functioning were consistent with the national average. Young participants appeared to suffer mentally more than older participants (p < 0.01 for depressive symptoms). Our findings suggest that patients may be at high risk of depressive symptoms, high anxiety, and low QOL even from the early stages of ART treatment.
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