ArticleScientific reports2021
The effect of dietary supplementation with Nigella sativa (black seeds) mediates immunological function in male Wistar rats.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Herbal synergy enhances growth performance, antioxidant status, immunity, and lymphoid tissue architecture in pigeons.Scientific reports · 2025Article
- The supplementation of dietary black cumin (Nigella Sativa) seeds on performance, blood hematology, post-metabolic responses, antioxidant status, immunity, and inflammatory markers in pre-weaning calves.Tropical animal health and production · 2025Article
- Potential of Secondary Metabolite Compounds of Black Cumin Seeds (Drug design, development and therapy · 2025Review
- Exploratory analysis of agro-morphological characteristics in Nigella sativa L. plant genotypes to determine mutagen colchicine ameliorative/ non-ameliorative impacts.Scientific reports · 2024Article
- Nutrient utilization, growth performance, and antioxidative status of Barki lambs fed diets supplemented with black (Nigella sativa) and rocket (Eruca sativa) seeds.Tropical animal health and production · 2024Article
- Evaluation of antioxidant, anti-inflammatory, anticancer activities and molecular docking of Moringa oleifera seed oil extract against experimental model of Ehrlich ascites carcinoma in Swiss female albino mice.BMC complementary medicine and therapies · 2023Article
- Article
- A proprietary black cumin oil extract (Frontiers in nutrition · 2023Article
- Magnetite-Based Nanostructured Coatings Functionalized withAntibiotics (Basel, Switzerland) · 2022Article
- Article
- Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This experiment aimed to investigate the effect of dietary Nigella sativa on the cell-mediated immune response. Eighteen male Wistar rats were divided equally into a control group and treated groups that received black seeds at rates of 30 and 50 g/kg in the diet (Sa30 and Sa50 groups, respectively, for 30 days. The weight gain, feed intake, feed conversion ratio (FCR), and cell-mediated immune response were monitored after the injection of 0.1 mL of 10% phytohemagglutinin (PHA). The intumesce index, serum total antioxidant capacity (TAC), catalase (CAT), interleukin-12 (IL-12), gamma interferon (γ-IF) and tumor necrosis factor alpha (TNF-α) were determined. Histopathological examination and an immunohistochemistry analysis of splenic caspase-3 and CD8 were performed. Nigella sativa significantly improved the weight gain and FCR. Intumesce index of Sa50 group was significantly increased. Nigella sativa significantly increased TAC, CAT, IL-12, γ-IF and TNF-α. A histological examination of PHA-stimulated foot pads showed increased leukocyte infiltration and edema in a dose-dependent pattern. Splenic caspase-3 and CD8 showed significant decreases and increases, respectively, in the Sa30 and Sa50 groups. The results indicate that Nigella sativa seeds exhibit immunostimulatory function through their antioxidant potential, induction of cytokine production, promotion of CD8 expression and reduction of splenic apoptosis.
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