ArticleNature communications2021
Robustness and plasticity in Drosophila heat avoidance.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Mating-Induced Behavioral Changes in FemaleInternational journal of molecular sciences · 2026Article
- Genetic inactivation of TRPM4 does not alter the temperature-dependent movement of mouse microglia.The journal of physiological sciences : JPS · 2026Article
- The Cellular and Circuit Basis of Temperature Sensation inAnnual review of neuroscience · 2026Review
- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- Article
- Cross-modal sensory compensation increases mosquito attraction to humans.Science advances · 2025Article
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
- The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish.Current biology : CB · 2024Article
- Rapid threat assessment in the Drosophila thermosensory system.Nature communications · 2023Article
- A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat.Current biology : CB · 2022Article
- Responses of different Drosophila species to temperature changes.The Journal of experimental biology · 2022Article
- Cool and warm ionotropic receptors control multiple thermotaxes inFrontiers in molecular neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Simple innate behavior is often described as hard-wired and largely inflexible. Here, we show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity in Drosophila. First, we demonstrate that hot receptor neurons of the antenna and their molecular heat sensor, Gr28B.d, are essential for flies to produce escape turns away from heat. High-resolution fly tracking combined with a 3D simulation of the thermal environment shows that, in steep thermal gradients, the direction of escape turns is determined by minute temperature differences between the antennae (0.1°-1 °C). In parallel, live calcium imaging confirms that such small stimuli reliably activate both peripheral thermosensory neurons and central circuits. Next, based on our measurements, we evolve a fly/vehicle model with two symmetrical sensors and motors (a "Braitenberg vehicle") which closely approximates basic fly thermotaxis. Critical differences between real flies and the hard-wired vehicle reveal that fly heat avoidance involves decision-making, relies on rapid learning, and is robust to new conditions, features generally associated with more complex behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.