Evidence map›Paper›PMID 33824210›Full record

ArticlemBio2021

Bifunctional Malic/Malolactic Enzyme Provides a Novel Mechanism for NADPH-Balancing in Bacillus subtilis.

Manuel Hörl, Tobias Fuhrer, Nicola Zamboni

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Microbiology spectrum · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Manuel HörlInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
Tobias FuhrerInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.ORCID 0000-0001-5006-6874
Nicola ZamboniInstitute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland nzamboni@ethz.ch.ORCID 0000-0003-1271-1021
ETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The redox cofactor NADPH is required as a reducing equivalent in about 100 anabolic reactions throughout metabolism. To ensure fitness under all conditions, the demand is fulfilled by a few dehydrogenases in central carbon metabolism that reduce NADP

Indexed as

Bacillus subtilisBacterial ProteinsGlucoseMalate DehydrogenaseMalatesNADPOxidation-ReductionBacterial ProteinsGlucoseMalate DehydrogenaseMalatesmalic acidmalolactic enzymeNADP13C metabolic flux analysisbifunctional enzymemalic enzymemalolactic enzymemetabolismNADPH balanceredox metabolism

Identifiers

PMID33824210
PMCPMC8092299
OpenAlexW3146290378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.