Evidence map›Paper›PMID 33824205›Full record

ArticlemBio2021

Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum.

Caitlin A Brennan, Geicho Nakatsu, Carey Ann Gallini Comeau, David A Drew, Jonathan N Glickman, Robert E Schoen, Andrew T Chan, Wendy S Garrett

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Review
  3. Pathogenic Roles ofPathogens (Basel, Switzerland) · 2026
    Review
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  6. Article
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  19. Article
  20. Research (Washington, D.C.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Caitlin A BrennanDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Geicho NakatsuDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Carey Ann Gallini ComeauDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
David A DrewClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jonathan N GlickmanDepartment of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Robert E SchoenDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew T ChanDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Wendy S GarrettDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA wgarrett@hsph.harvard.edu.
Harvard University · USUniversity of Pittsburgh · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Precision Prevention Research ProgramR35CA253185 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew T Chan · 2020 to 2026
$6.9M
Refinement and Discovery of Nuclear Matrix Protein Markers for Colorectal CancerU01CA152753 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINZLER, KENNETH W., SCHOEN, ROBERT E. · 2010 to 2021
$6.8M
Gut microbiota and inflammatory monocytes in colorectal cancerR01CA154426 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI GARRETT, WENDY S. · 2011 to 2025
$5.2M
Dietary sulfur, the gut microbiome, and colorectal cancerR01CA202704 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, GARRETT, WENDY S. · 2016 to 2020
$2.8M
Cancer Immunology Training GrantT32CA207021 · NCI · DANA-FARBER CANCER INST · PI WUCHERPFENNIG, KAI W · 2016 to 2020
$2.4M
Impact of Aspirin on the Gut Microbiome and Mucosal MicroenvironmentK01DK120742 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DREW, DAVID A · 2020 to 2024
$793k
Cancer Research UK 27140NCI NIH HHS R01 CA154426NCI NIH HHS R01 CA202704NCI NIH HHS R35 CA253185NCI NIH HHS T32 CA207021NCI NIH HHS U01 CA152753NIDDK NIH HHS K01 DK120742NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Aspirin is a chemopreventive agent for colorectal adenoma and cancer (CRC) that, like many drugs inclusive of chemotherapeutics, has been investigated for its effects on bacterial growth and virulence gene expression. Given the evolving recognition of the roles for bacteria in CRC, in this work, we investigate the effects of aspirin with a focus on one oncomicrobe-

Indexed as

AdenomaAnimalsAspirinBacteriaCarcinogenesisCell Transformation, NeoplasticColonColorectal NeoplasmsFemaleFusobacterium nucleatumHumansMaleMiceAspirinaspirincolon cancerFusobacterium nucleatum

Identifiers

PMID33824205
PMCPMC8092249
OpenAlexW3150498393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.