Evidence map›Paper›PMID 33823890›Full record

ArticleItalian journal of pediatrics2021

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study.

Belete Gelaw, Getasew Mulatu, Getasew Tesfa, Chalie Marew, Bogale Chekole, Animut Alebel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Belete GelawSchool of Nursing, College of Medicine and Health Sciences, Wolaita Sodo University, Sodo, Ethiopia. beletegz12@gmail.com.ORCID http://orcid.org/0000-0001-6965-8466
Getasew MulatuCollege of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Getasew TesfaCollege of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Chalie MarewCollege of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Bogale ChekoleCollege of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia.
Animut AlebelCollege of Health Science, Debre Markos University, Debre Markos, Ethiopia.
Bahir Dar University · ETDebre Tabor University · ETUniversity of Technology Sydney · AUWolaita Sodo University · ETWolkite University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach to identify treatment failure and develop public health interventions in children receiving antiretroviral therapy. Thus, this study aims to assess the magnitude and associated factors of virological failure among children on antiretroviral therapy.

methodsA facility-based cross-sectional study was conducted among 399 HIV-positive children on antiretroviral therapy from 2016 to 2019 in Bahir Dar Town public health facilities. Data were extracted from children's charts using a standardized data extraction tool, adapted from ART intake and follow-up forms. Data were entered using Epi-Data Version 3.1, and analyzed using SPSS Version 25. Bivariable and multivariable binary logistic regression models were done to identify factors associated with virological failure. Variables with p-values < 0.25 were fitted into the multivariable analysis. Finally, variables with p-values <0.05 were considered as statistically significant factors.

resultsThe period prevalence of virological failure was found to be 14.8% (95% CI: 11.5-19.3%). Opportunistic infections (AOR = 2.19, CI: 1.13-4.25), history of treatment interruption and restart (AOR = 2.21, CI: 1.09-4.54), younger age (AOR = 2.42, CI: 1.02-5.74), poor/fair ART adherence (AOR = 2.19, CI: 1.05-4.57), and advanced baseline WHO clinical staging (AOR = 2.32, CI: 1.14-4.74) were found to be factors significantly associated with virological failure.

conclusionThe magnitude of virological failure among HIV-infected children remained high. Children with poor/fair ART adherence, history of treatment interruption, advanced baseline WHO clinical staging, younger age, and opportunistic infections were significantly associated with virologic failure. Thus, special attention should be given to children who had poor/fair ART adherence and presenting with opportunistic infections.

Indexed as

Viral LoadAdolescentAge FactorsAnti-Retroviral AgentsChildChild, PreschoolCross-Sectional StudiesEthiopiaFemaleHIV InfectionsHumansInfantInfant, NewbornMaleMedication AdherenceOpportunistic InfectionsAnti-Retroviral AgentsAntiretroviral therapyBahir DarChildrenHIVVirological failure

Identifiers

PMID33823890
PMCPMC8025328
OpenAlexW3121344925

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.