Evidence map›Paper›PMID 33823885›Full record

ArticleRadiation oncology (London, England)2021

Biologically consistent dose accumulation using daily patient imaging.

Nina I Niebuhr, Mona Splinter, Tilman Bostel, Joao Seco, Clemens M Hentschke, Ralf O Floca, Juliane Hörner-Rieber, Markus Alber, Peter Huber, Nils H Nicolay and 1 more

Abstract read
In one paragraph

Article in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. First dosimetric evaluation of deformable dose accumulation in human individuals.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  2. Article
  3. Review
  4. Applicability and usage of dose mapping/accumulation in radiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nina I NiebuhrMedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. nina.niebuhr@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-5749-9645
Mona SplinterMedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tilman BostelClinical Cooperation Unit "Radiation Oncology", German Cancer Research Center (DKFZ), Heidelberg, Germany.
Joao SecoDepartment of Physics and Astronomy, Heidelberg University, Heidelberg, Germany.
Clemens M HentschkeHeidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
Ralf O FlocaHeidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
Juliane Hörner-RieberHeidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
Markus AlberHeidelberg Institute for Radiooncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
Peter HuberClinical Cooperation Unit "Radiation Oncology", German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nils H Nicolay *Clinical Cooperation Unit "Radiation Oncology", German Cancer Research Center (DKFZ), Heidelberg, Germany.
Asja Pfaffenberger *Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the linear quadratic model (LQM). To overcome this inconsistency, we introduce and evaluate the concept of the total biological dose, bEQD

methodsDaily computed tomography imaging of nine patients treated for prostate carcinoma with intensity-modulated radiotherapy was used to compute the delivered deformed dose on the basis of deformable image registration (DIR). We compared conventional dose accumulation (DA) with the newly introduced bEQD

resultsbEQD

conclusionUsing bEQD

Indexed as

HumansMaleOrgans at RiskProstatic NeoplasmsRadiation Dose HypofractionationRadiotherapy DosageRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedUncertaintyDelivered doseDose accumulationImage guidanceLinear quadratic modelNormal tissue responseRadiobiology

Identifiers

PMID33823885
PMCPMC8025323

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.