ReviewBMC genomics2021
Gene co-expression network analysis reveals key pathways and hub genes in Chinese cabbage (Brassica rapa L.) during vernalization.
Review in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- Association between nasal airway metabolome signatures and lung function at age 6 years among children with post-bronchiolitis asthma.ERJ open research · 2026Article
- Comprehensive evaluation of the heat tolerance of non-heading Chinese cabbage based on multifactorial statistical analysis.Frontiers in plant science · 2026Article
- Identification of Genetic Diagnostic Markers for Systemic Lupus Erythematosus.Genetics research · 2026Article
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- Identification of hub genes, diagnostic model, and immune infiltration in preeclampsia by integrated bioinformatics analysis and machine learning.BMC pregnancy and childbirth · 2024Article
- Orphan geneHorticulture research · 2024Article
- Single-cell transcriptomic analysis of flowering regulation and vernalization in Chinese cabbage shoot apex.Horticulture research · 2024Article
- Bioinformatics and Machine Learning Methods Identified MGST1 and QPCT as Novel Biomarkers for Severe Acute Pancreatitis.Molecular biotechnology · 2024Article
- lncRNA TTTY14 participates in the progression of repeated implantation failure by regulating the miR-6088/SEMA5A axis.Journal of assisted reproduction and genetics · 2024Article
- Genome-Wide Association Study for Maize Hybrid Performance in a Typical Breeder Population.International journal of molecular sciences · 2024Article
- Weighted gene co-expression network analysis reveals immune evasion related genes inExperimental biology and medicine (Maywood, N.J.) · 2024Article
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- CRISPR/Cas9-MediatedInternational journal of molecular sciences · 2023Article
- Identification of key module and hub genes in pulpitis using weighted gene co-expression network analysis.BMC oral health · 2023Article
- The Skeletal Muscle Transcriptome Profile of Elderly Men with Metabolic Syndrome Based on Weighted Gene Co-Expression Network Analysis.Obesity facts · 2023Article
- Identification of long noncoding RNAs involved in plumule-vernalization of Chinese cabbage.Frontiers in plant science · 2023Article
- Comparison of the transcriptome and metabolome of wheat (Frontiers in plant science · 2023Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundVernalization is a type of low temperature stress used to promote rapid bolting and flowering in plants. Although rapid bolting and flowering promote the reproduction of Chinese cabbages (Brassica rapa L. ssp. pekinensis), this process causes their commercial value to decline. Clarifying the mechanisms of vernalization is essential for its further application. We performed RNA sequencing of gradient-vernalization in order to explore the reasons for the different bolting process of two Chinese cabbage accessions during vernalization.
resultsThere was considerable variation in gene expression between different-bolting Chinese cabbage accessions during vernalization. Comparative transcriptome analysis and weighted gene co-expression network analysis (WGCNA) were performed for different-bolting Chinese cabbage during different vernalization periods. The biological function analysis and hub gene annotation of highly relevant modules revealed that shoot system morphogenesis and polysaccharide and sugar metabolism caused early-bolting 'XBJ' to bolt and flower faster; chitin, ABA and ethylene-activated signaling pathways were enriched in late-bolting 'JWW'; and leaf senescence and carbohydrate metabolism enrichment were found in the two Chinese cabbage-related modules, indicating that these pathways may be related to bolting and flowering. The high connectivity of hub genes regulated vernalization, including MTHFR2, CPRD49, AAP8, endoglucanase 10, BXLs, GATLs, and WRKYs. Additionally, five genes related to flower development, BBX32 (binds to the FT promoter), SUS1 (increases FT expression), TSF (the closest homologue of FT), PAO and NAC029 (plays a role in leaf senescence), were expressed in the two Chinese cabbage accessions.
conclusionThe present work provides a comprehensive overview of vernalization-related gene networks in two different-bolting Chinese cabbages during vernalization. In addition, the candidate pathways and hub genes related to vernalization identified here will serve as a reference for breeders in the regulation of Chinese cabbage production.
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