Evidence map›Paper›PMID 33823778›Full record

ArticleCurrent neurovascular research2021

CD31+ Circulating Angiogenic Cell Number and Subtypes are Reduced in Individuals with Chronic Stroke.

Rian Q Landers-Ramos, Katherine I Kim, Brent Hickey, Frederick M Ivey, Charlene E Hafer-Macko, Richard F Macko, Alice S Ryan, Steven J Prior

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neurovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rian Q Landers-RamosDepartment of Kinesiology, Towson University, Towson, MD, United States.
Katherine I KimDepartment of Kinesiology, University of Maryland School of Public Health, College Park, MD, United States.
Brent HickeyDepartment of Kinesiology, Towson University, Towson, MD, United States.
Frederick M IveyGeriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD, United States.
Charlene E Hafer-MackoGeriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD, United States.
Richard F MackoGeriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD, United States.
Alice S RyanGeriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD, United States.
Steven J PriorGeriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD, United States.
Geriatric Research Education and Clinical Center · USTowson University · USUniversity of Maryland, College Park · US

Funding

Vascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7M
Aging, Inflammation and Exercise in Chronic StrokeR01AG030075 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI HAFER-MACKO, CHARLENE E, RYAN, ALICE S. · 2008 to 2012
$2.4M
Effects of Aerobic Exerise on EPCs and Vascular Dysfunction in Aging and T2DMK23AG040775 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI PRIOR, STEVEN J · 2012 to 2014
$532k
CSRD VA I01 CX000730Department of VA Merit Review Award I01-CX000730NHLBI NIH HHS T32 HL007698NIA NIH HHS K23 AG040775NIA NIH HHS R01 AG030075
6 · The paper itself

Abstract

background and purposeReduced number and function of CD31+ circulating angiogenic cells (CACs) may explain vascular complications associated with the chronic phase stroke. The purpose of this study was to quantify CD31+ CAC paracrine function, total number and number of various subtypes of CD31+ CACs in individuals with chronic stroke compared with controls.

methodsPeripheral blood mononuclear cells were isolated from chronic stroke participants and controls. CD31+ cells were quantified by flow cytometry, as was co-expression of CD31 in combination with CD14, CD3, CD11b, or CD34. Immunomagnetically selected CD31+ cells were cultured, and conditioned medium was used in a capillary-like network assay.

resultsSignificantly lower levels of CD31+ CACs were found in stroke participants compared with controls (-24%; P=0.04). Additionally, CD31+/CD14+, CD31+/CD11b+ and CD31+/CD3+ cells were significantly lower in the chronic stroke group compared with controls (-45%, P=0.02; -47%, P=0.02 and -32%, P=0.03, respectively). There was no group effect on CD31+ CAC conditioned media-mediated capillary-like network formation.

conclusionCD31+ CACs and subtypes may serve as potential therapeutic targets in chronic stroke recovery.

Indexed as

FemaleHumansLeukocyte CountLeukocytes, MononuclearMaleMiddle AgedNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1StrokePlatelet Endothelial Cell Adhesion Molecule-1angiogenesis.angiogenic T cellCD31chronic strokeCirculating angiogenic cellsparacrine

Identifiers

PMID33823778
PMCPMC12757809
OpenAlexW3144546082

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.