Evidence map›Paper›PMID 33823663›Full record

ArticleOpen biology2021

A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Lenka Halova, David Cobley, Mirita Franz-Wachtel, Tingting Wang, Kaitlin R Morrison, Karsten Krug, Nicolas Nalpas, Boris Maček, Iain M Hagan, Sean J Humphrey and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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  11. The Catalytic Subunit ofInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Lenka HalovaFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
David CobleyFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Mirita Franz-WachtelProteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
Tingting WangFlinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia 5042, Australia.
Kaitlin R MorrisonFlinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia 5042, Australia.
Karsten KrugProteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
Nicolas NalpasProteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
Boris MačekProteome Center Tuebingen, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany.
Iain M HaganCancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, UK.
Sean J HumphreyCharles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, Australia.
Janni PetersenFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
University of Tübingen · DEFlinders University · AUUniversity of Manchester · GBCancer Research UK Manchester Institute · GBThe University of Sydney · AU

Funding

Cancer Research UK 24458Cancer Research UK C10888/A11178
6 · The paper itself

Abstract

Fluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled signalling in the fission yeast

Indexed as

ProteomeBiomarkersCell CycleComputational BiologyEnergy MetabolismGene OntologyHost Microbial InteractionsHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NitrogenPhosphoproteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsSignal TransductionStress, PhysiologicalBiomarkersMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NitrogenPhosphoproteinsProteomeSchizosaccharomyces pombe ProteinsTOR Serine-Threonine KinasesByr1 MAPKKfission yeast Schizosaccharomyces pombenitrogen stressphosphoproteomeTORC1TORC2

Identifiers

PMID33823663
PMCPMC8025308
OpenAlexW3144553740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.