ArticleBiosensors & bioelectronics2021
Rapid and unamplified identification of COVID-19 with morpholino-modified graphene field-effect transistor nanosensor.
Article in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 190 citations in OpenAlex.
- Nanosensors in food safety detection: a comprehensive review of recent advances and future prospects.Mikrochimica acta · 2026Review
- Recent Advances in Graphene-Based Field-Effect Transistor Biosensors for Disease Biomarker Detection and Clinical Prospects.Biosensors · 2026Review
- Indium Tin Oxide-Based Voltammetric Biosensor for the Detection of Antibodies Against the SARS-CoV-2 Virus Spike Protein.Sensors (Basel, Switzerland) · 2025Article
- Recent Advances in Xenes Based FET for Biosensing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Emerging Trends of Gold Nanostructures for Point-of-Care Biosensor-Based Detection of COVID-19.Molecular biotechnology · 2025Review
- Advancing Frontiers: Graphene-Based Nano-biosensor Platforms for Cutting-Edge Research and Future Innovations.Indian journal of microbiology · 2025Article
- AlHeliyon · 2024Article
- A portable transistor immunosensor for fast identification of porcine epidemic diarrhea virus.Journal of nanobiotechnology · 2024Article
- Recent Advances in Field-Effect Transistor-Based Biosensors for Label-Free Detection of SARS-CoV-2.Small science · 2024Article
- Advances in lithographic techniques for precision nanostructure fabrication in biomedical applications.Discover nano · 2023Review
- The Application of Graphene Field-Effect Transistor Biosensors in COVID-19 Detection Technology: A Review.Sensors (Basel, Switzerland) · 2023Review
- Two-Dimensional (2D) materials in the detection of SARS-CoV-2.Microchemical journal : devoted to the application of microtechniques in all branches of science · 2023Article
- Carbon-based biosensors: Next-generation diagnostic tool for target-specific detection of SARS-CoV-2 (COVID-19).Talanta open · 2023Article
- Ultra-sensitive specific detection of nucleic acids in pathogenic infections by TaSensors and actuators. B, Chemical · 2023Article
- Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution.Carbon · 2023Review
- Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms.Chinese chemical letters = Zhongguo hua xue kuai bao · 2023Review
- Nano-biosensor for SARS-CoV-2/COVID-19 detection: methods, mechanism and interface design.RSC advances · 2023Review
- A Sensitive Biosensor Based on Plasmonic-Graphene Configuration for Detection of COVID-19 Virus.Plasmonics (Norwell, Mass.) · 2023Article
- Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives.Journal of nanobiotechnology · 2023Review
- Using Nanomaterials for SARS-CoV-2 Sensing via Electrochemical Techniques.Micromachines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SARS-CoV-2 RNA is identified as a pivotal player to bolster energizing zones of COVID-19 detection. Herein, we develop a rapid and unamplified nanosensing platform for detection of SARS-CoV-2 RNA in human throat swab specimens. A gold nanoparticle (AuNP)-decorated graphene field-effect transistor (G-FET) sensor was fabricated, after which complementary phosphorodiamidate morpholino oligos (PMO) probe was immobilized on the AuNP surface. This sensor allowed for highly sensitive testing of SARS-CoV-2 RdRp as PMO does not have charges, leading to low background signal. Not only did the method present a low limit of detection in PBS (0.37 fM), throat swab (2.29 fM), and serum (3.99 fM), but also it achieved a rapid response to COVID-19 patients' samples within 2 min. The developed nanosensor was capable of analyzing RNA extracts from 30 real clinical samples. The results show that the sensor could differentiate the healthy people from infected people, which are in high agreement with RT-PCR results (Kappa index = 0.92). Furthermore, a well-defined distinction between SARS-CoV-2 RdRp and SARS-CoV RdRp was also made. Therefore, we believe that this work provides a satisfactory, attractive option for COVID-19 diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.