ArticleNeuroImage. Clinical2021
Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Altered brain-behavior coupling during inhibitory control in ankylosing spondylitis: ERP evidence from NoGo-P3 component.PloS one · 2026Article
- Altered functional connectivity within and between resting-state networks in ulcerative colitis.Brain imaging and behavior · 2025Article
- Changes in white matter microstructure in the brain of patients with inflammatory bowel disease are associated with abdominal pain.Frontiers in neuroscience · 2025Article
- Nutritional Modulation of the Gut-Brain Axis: A Comprehensive Review of Dietary Interventions in Depression and Anxiety Management.Metabolites · 2024Review
- Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI.Scientific reports · 2024Article
- Neuroplasticity of the white matter tracts underlying recovery of diarrhea-predominant irritable bowel syndrome following acupuncture treatment.Frontiers in neuroscience · 2024Article
- Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health.Journal of Crohn's & colitis · 2023Article
- Immunoception: the insular cortex perspective.Cellular & molecular immunology · 2023Review
- Symptom management needs of patients with irritable bowel syndrome and concurrent anxiety and/or depression: A qualitative study.Journal of advanced nursing · 2023Article
- Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023Article
- Brain structure and function changes in inflammatory bowel disease.Neuroimage. Reports · 2022Article
- Structure can predict function in the human brain: a graph neural network deep learning model of functional connectivity and centrality based on structural connectivity.Brain structure & function · 2022Article
- Brain Network Topology and Structural-Functional Connectivity Coupling Mediate the Association Between Gut Microbiota and Cognition.Frontiers in neuroscience · 2022Article
- Brain structure and function changes in ulcerative colitis.Neuroimage. Reports · 2021Article
- Altered Structural Covariance of Insula, Cerebellum and Prefrontal Cortex Is Associated with Somatic Symptom Levels in Irritable Bowel Syndrome (IBS).Brain sciences · 2021Article
- Altered Brain Structure in Chronic Visceral Pain: Specific Differences in Gray Matter Volume and Associations With Visceral Symptoms and Chronic Stress.Frontiers in neurology · 2021Article
- Higher Levels of Psychological Burden and Alterations in Personality Functioning in Crohn's Disease and Ulcerative Colitis.Frontiers in psychology · 2021Article
- Alexithymic characteristics and interoceptive abilities are associated with disease severity and levels of C-reactive protein and cytokines in patients with inflammatory bowel disease.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveWe aimed to identify differences in network properties of white matter microstructure between asymptomatic ulcerative colitis (UC) participants who had a history of chronic gut inflammation, healthy controls (HCs) and a disease control group without gut inflammation (irritable bowel syndrome; IBS).
designDiffusion weighted imaging was conducted in age and sex-matched participants with UC, IBS, and HCs (N = 74 each), together with measures of gastrointestinal and psychological symptom severity. Using streamline connectivity matrices and graph theory, we aimed to quantify group differences in brain network connectivity. Regions showing group connectivity differences were correlated with measures showing group behavioral and clinical differences.
resultsUC participants exhibited greater centrality in regions of the somatosensory network and default mode network, but lower centrality in the posterior insula and globus pallidus compared to HCs (q < 0.05). Hub analyses revealed compromised hubness of the pallidus in UC and IBS compared to HCs which was replaced by increased hubness of the postcentral sulcus. Surprisingly, few differences in network matrices between UC and IBS were identified. In UC, centrality measures in the secondary somatosensory cortex were associated with depression (q < 0.03), symptom related anxiety (q < 0.04), trait anxiety (q < 0.03), and symptom duration (q < 0.05).
conclusionA history of UC is associated with neuroplastic changes in several brain networks, which are associated with symptoms of depression, trait and symptom-related anxiety, as well as symptom duration. When viewed together with the results from IBS subjects, these findings suggest that chronic gut inflammation as well as abdominal pain have a lasting impact on brain network organization, which may play a role in symptoms reported by UC patients, even when gut inflammation has subsided.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.