Evidence map›Paper›PMID 33823121›Full record

ArticleHuman vaccines & immunotherapeutics2021

Quantitative characterization of the T cell receptor repertoires of human immunized by rabies virus vaccine.

Pingsen Zhao, Kaijian Hou, Zhixiong Zhong, Sharula Guo, Songtao Yang, Xianzhu Xia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Pingsen ZhaoDepartment of Laboratory Medicine, Yuebei People's Hospital, Shantou University Medical College, Shaoguan, China.
Kaijian HouDepartment of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Zhixiong ZhongCenter for Precision Medicine, Meizhou People's Hospital, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, China.
Sharula GuoDepartment of Infection Control, Yuebei People's Hospital, Shantou University Medical College, Shaoguan, China.
Songtao YangAcademy of Military Medical Sciences, Institute of Military Veterinary, Changchun, China.
Xianzhu XiaLaboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Shantou University Medical College, Shaoguan, China.
Academy of Military Medical Sciences · CNMeizhou City People's Hospital · CNShantou University · CNShantou University Medical College · CNYue Bei People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the T cell receptor (TCR) repertoire in human after RABV vaccine immunization remained unclear. In this study, we conducted high-throughput sequencing of TCR β chain complementarity determining region 3(CDR3) repertoires in 4 healthy volunteers before and after immunization with RABV vaccine. Our data showed that RABV vaccination changed the TCR diversity and the usage of V/J gene segments, as well as V-J pairing. The high-frequency clonotypes that altered after vaccination were identified. These results may provide us with new insights into T cell receptor condition after RABV vaccination.

Indexed as

Rabies VaccinesRabies virusComplementarity Determining RegionsHumansReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaComplementarity Determining RegionsRabies VaccinesReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betacomplementarity determining region 3(CDR3)high-throughput sequencingimmune responseRabies virus (RABV)T cell receptor (TCR) repertoire

Identifiers

PMID33823121
PMCPMC8475554
OpenAlexW3147235473

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.