ArticleJournal of neuropathology and experimental neurology2021
Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term.
Article in Journal of neuropathology and experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Charting the Normal Development of Structural Brain Connectivity in Utero Using Diffusion MRI.Human brain mapping · 2026Article
- Prenatal exposure to hypertensive disorders and adolescent brain white matter development.Pediatric research · 2026Article
- Fidgety Movement Classification in Preterm Infants Without Major Structural Brain Abnormalities: Associations with Gestational Age, Birth Weight, and Neonatal Morbidity.Children (Basel, Switzerland) · 2026Article
- Postnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism.bioRxiv : the preprint server for biology · 2026Article
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- Assessing infants' sleep in the home setting: designing rational study approaches.Pediatric research · 2026Review
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Brain complexity in response to auditory stimulation improves evaluation of cerebral maturation in premature newborns.Pediatric research · 2026Article
- Prenatal Azithromycin Exposure and Risk of Neurodevelopmental Disorders in Children.JAMA network open · 2026Article
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex.Nature communications · 2026Article
- Prenatal antiseizure drug exposure and risk of neurodevelopmental disorders in children: population based cohort study.BMJ (Clinical research ed.) · 2026Article
- Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026Article
- Prenatal Exposure to Wildfire and Autism in Children.Environmental science & technology · 2026Article
- Rhythm Processing Across Development: Origins, Links to Language Processing, and Perspectives for Intervention.Annals of the New York Academy of Sciences · 2026Review
- Dysfunctional brain connectivity and cognition in late preterm infants: novel perspectives on neurodevelopment and learning.Frontiers in synaptic neuroscience · 2026Review
- Heparan sulphate and neural development: dissecting the roles of astrocyte-expressed heparan sulphate.Biochemical Society transactions · 2025Review
- Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.BMC medicine · 2025Article
- Precision functional imaging in infants using multi-echo fMRI at 7T.bioRxiv : the preprint server for biology · 2025Article
- Insights into Temporal and Spatial Dynamics of Short Association Fiber Formation in the Human Fetal Brain.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the second half of gestation, the human cerebrum undergoes pivotal histogenetic events that underlie functional connectivity. These include the growth, guidance, selection of axonal pathways, and their first engagement in neuronal networks. Here, we characterize the spatiotemporal patterns of cerebral connectivity in extremely preterm (EPT), very preterm (VPT), preterm and term babies, focusing on magnetic resonance imaging (MRI) and histological data. In the EPT and VPT babies, thalamocortical axons enter into the cortical plate creating the electrical synapses. Additionally, the subplate zone gradually resolves in the preterm and term brain in conjunction with the growth of associative pathways leading to the activation of large-scale neural networks. We demonstrate that specific classes of axonal pathways within cerebral compartments are selectively vulnerable to temporally nested pathogenic factors. In particular, the radial distribution of axonal lesions, that is, radial vulnerability, is a robust predictor of clinical outcome. Furthermore, the subplate tangential nexus that we can visualize using MRI could be an additional marker as pivotal in the development of cortical connectivity. We suggest to direct future research toward the identification of sensitive markers of earlier lesions, the elucidation of genetic mechanisms underlying pathogenesis, and better long-term follow-up using structural and functional MRI.
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