ArticleCerebral cortex (New York, N.Y. : 1991)2021
Drifts in Prefrontal and Parietal Neuronal Activity Influence Working Memory Judgments.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Working memory expedites the processing of visual signals within the extrastriate cortex.iScience · 2024Article
- Contributions of narrow- and broad-spiking prefrontal and parietal neurons on working memory tasks.Frontiers in systems neuroscience · 2024Article
- Single-neuron and population measures of neuronal activity in working memory tasks.Journal of neurophysiology · 2023Article
- Dynamical latent state computation in the male macaque posterior parietal cortex.Nature communications · 2023Article
- Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance.Frontiers in behavioral neuroscience · 2023Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The dorsolateral prefrontal cortex (dlPFC) plays a critical role in spatial working memory and its activity predicts behavioral responses in delayed response tasks. Here, we addressed if this predictive ability extends to other working memory tasks and if it is present in other brain areas. We trained monkeys to remember the location of a stimulus and determine whether a second stimulus appeared at the same location or not. Neurophysiological recordings were performed in the dorsolateral prefrontal cortex and posterior parietal cortex (PPC). We hypothesized that random drifts causing the peak activity of the network to move away from the first stimulus location and toward the location of the second stimulus would result in categorical errors. Indeed, for both areas, in nonmatching trials, when the first stimulus appeared in a neuron's preferred location, the neuron showed significantly higher firing rates in correct than in error trials; and vice versa, when the first stimulus appeared at a nonpreferred location, activity in error trials was higher than in correct. The results indicate that the activity of both dlPFC and PPC neurons is predictive of categorical judgments of information maintained in working memory, and neuronal firing rate deviations are revealing of the contents of working memory.
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Registered trials
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