ArticleCerebral cortex (New York, N.Y. : 1991)2021
Phenotyping the Preterm Brain: Characterizing Individual Deviations From Normative Volumetric Development in Two Large Infant Cohorts.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Cross-population white matter atlas creation for concurrent mapping of brain connections in neonates and adults with diffusion MRI tractography.Fundamental research · 2026Article
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
- Volumetric analysis of term-equivalent age MRI in post-haemorrhagic ventricular dilatation reveals association between deep grey matter volume and developmental outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Edge participation coefficient unveiling the developmental dynamics of neonatal functional connectome.Communications biology · 2025Article
- Heterogeneous, temporally consistent, and plastic brain development after preterm birth.Nature communications · 2025Article
- Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.Biology of sex differences · 2025Article
- A lifespan-generalizable skull-stripping model for magnetic resonance images that leverages prior knowledge from brain atlases.Nature biomedical engineering · 2025Article
- Contrasting neonatal brain morphometry and its impact on neurodevelopmental outcome between preterm birth and congenital heart disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neonatal hypoxia: impacts on the developing mind and brain.Frontiers in cognition · 2025Review
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China.Scientific data · 2024Article
- Comprehensive analysis of synthetic learning applied to neonatal brain MRI segmentation.Human brain mapping · 2024Article
- Individualized cortical gyrification in neonates with congenital heart disease.Brain communications · 2024Article
- Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors.Journal of the American Heart Association · 2023Article
- Comprehensive volumetric phenotyping of the neonatal brain in Down syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Normative models for neuroimaging markers: Impact of model selection, sample size and evaluation criteria.NeuroImage · 2023Article
- Extreme prematurity and perinatal risk factors related to extremely preterm birth are associated with complex patterns of regional brain volume alterations at 10 years of age: a voxel-based morphometry study.Frontiers in neurology · 2023Article
- Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age.NeuroImage · 2021Article
- Individualized brain development and cognitive outcome in infants with congenital heart disease.Brain communications · 2021Article
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Authors and funding
29 authors at 4 institutions in 3 countries.
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Abstract
The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead of focusing on describing effects common to the group, comparing individual infants against robust normative data offers a powerful alternative to study brain maturation. Here we used Gaussian process regression to create normative curves characterizing brain volumetric development in 274 term-born infants, modeling for age at scan and sex. We then compared 89 preterm infants scanned at term-equivalent age with these normative charts, relating individual deviations from typical volumetric development to perinatal risk factors and later neurocognitive scores. To test generalizability, we used a second independent dataset comprising of 253 preterm infants scanned using different acquisition parameters and scanner. We describe rapid, nonuniform brain growth during the neonatal period. In both preterm cohorts, cerebral atypicalities were widespread, often multiple, and varied highly between individuals. Deviations from normative development were associated with respiratory support, nutrition, birth weight, and later neurocognition, demonstrating their clinical relevance. Group-level understanding of the preterm brain disguises a large degree of individual differences. We provide a method and normative dataset that offer a more precise characterization of the cerebral consequences of preterm birth by profiling the individual neonatal brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.