ArticlePloS one2021
Trajectories of healthy ageing among older adults with multimorbidity: A growth mixture model using harmonised data from eight ATHLOS cohorts.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Occupational polycyclic aromatic hydrocarbons (PAHs) exposure is associated with accelerated aging trajectories in Chinese coke oven workers.Scientific reports · 2026Article
- Urbanization exacerbates age-associated declines in cardiometabolic health in Turkana and Orang Asli.medRxiv : the preprint server for health sciences · 2025Article
- Acute stroke in persons 85 years or older-clinical characteristics, impact of frailty, and predictors of outcome.Frontiers in neurology · 2025Article
- Transitions in intrinsic capacity among community-dwelling older people and their associated factors: a multistate modelling analysis.The journal of nutrition, health & aging · 2024Article
- Article
- Studying the Changes in Physical Functioning and Oxidative Stress-Related Molecules in People Living with HIV after Switching from Triple to Dual Therapy.Antioxidants (Basel, Switzerland) · 2024Article
- Place of care in the last three years of life for Medicare beneficiaries.BMC geriatrics · 2024Article
- Rehabilitation in primary care for an ageing population: a secondary analysis from a scoping review of rehabilitation delivery models.BMC health services research · 2024Article
- Article
- Measuring healthy ageing: current and future tools.Biogerontology · 2023Review
- Are adverse childhood experiences associated with trajectories of healthy aging? Evidence from China.SSM - population health · 2023Article
- Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort.BMC medicine · 2023Article
- Effects of multimorbidity coexistence on the risk of mortality in the older adult population in China.Frontiers in public health · 2023Article
- Trajectories of Intrinsic Capacity: Determinants and Associations with Disability.The journal of nutrition, health & aging · 2023Article
- Editorial: Sarcopenia, Cognitive Function, and the Heterogeneity in Aging.The journal of nutrition, health & aging · 2023Article
- Effect of the Juggling-Based Motor Learning Physical Activity on Well-Being in Elderly: A Pre-Post Study with a Special Training Protocol.Healthcare (Basel, Switzerland) · 2022Article
- A Digital Health Service for Elderly People with Balance Disorders and Risk of Falling: A Design Science Approach.International journal of environmental research and public health · 2022Article
- How aging of the global population is changing oncology.Ecancermedicalscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesIn this study we aimed to 1) describe healthy ageing trajectory patterns, 2) examine the association between multimorbidity and patterns of healthy ageing trajectories, and 3) evaluate how different groups of diseases might affect the projection of healthy ageing trajectories over time. SETTING AND
participantsOur study was based on 130880 individuals from the Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS) harmonised dataset, as well as 9171 individuals from Waves 2-7 of the English Longitudinal Study of Ageing (ELSA).
methodsUsing a healthy ageing index score, which comprised 41 items, covering various domains of health and ageing, as outcome, we employed the growth mixture model approach to identify the latent classes of individuals with different healthy ageing trajectories. A multinomial logistic regression was conducted to assess if and how multimorbidity status and multimorbidity patterns were associated with changes in healthy ageing, controlled for sociodemographic and lifestyle risk factors.
resultsThree similar patterns of healthy ageing trajectories were identified in the ATHLOS and ELSA datasets: 1) a 'high stable' group (76% in ATHLOS, 61% in ELSA), 2) a 'low stable' group (22% in ATHLOS, 36% in ELSA) and 3) a 'rapid decline' group (2% in ATHLOS, 3% in ELSA). Those with multimorbidity were 1.7 times (OR = 1.7, 95% CI: 1.4-2.1) more likely to be in the 'rapid decline' group and 11.7 times (OR = 11.7 95% CI: 10.9-12.6) more likely to be in the 'low stable' group, compared with people without multimorbidity. The cardiorespiratory/arthritis/cataracts group was associated with both the 'rapid decline' and the 'low stable' groups (OR = 2.1, 95% CI: 1.2-3.8 and OR = 9.8, 95% CI: 7.5-12.7 respectively).
conclusionHealthy ageing is heterogeneous. While multimorbidity was associated with higher odds of having poorer healthy ageing trajectories, the extent to which healthy ageing trajectories were projected to decline depended on the specific patterns of multimorbidity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.