Evidence map›Paper›PMID 33822577›Full record

ArticleACS infectious diseases2021

Opportunities and Challenges in Developing a

Rajiv S Jumani, Johanne Blais, Hanns-Christian Tillmann, Florencia Segal, Dean Wetty, Christian Ostermeier, Natko Nuber, Jay Lakshman, Natasha Aziz, Richa Chandra and 4 more

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Frontiers in veterinary science · 2026
    Review
  3. Article
  4. Review
  5. Science translational medicine · 2024
    Article
  6. Biopreserving Pathogens: Promise & Peril.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2024
    Article
  7. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2024
    Article
  8. Article
  9. Review
  10. An update onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Review
  11. Prevalence ofGastroenterology and hepatology from bed to bench · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Rajiv S JumaniNovartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States.
Johanne BlaisNovartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States.
Hanns-Christian TillmannNovartis Institutes for BioMedical Research, Inc., Translational Medicine, 4056 Basel, Switzerland.
Florencia SegalNovartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts 02139-4133, United States.
Dean WettyNovartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts 02139-4133, United States.
Christian OstermeierNovartis Pharma AG, 4002 Basel, Switzerland.
Natko NuberNovartis Pharma AG, 4002 Basel, Switzerland.
Jay LakshmanNovartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, United States.
Natasha AzizNovartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States.
Richa ChandraNovartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, United States.
Wilbur H ChenCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Cynthia L ChappellThe University of Texas School of Public Health Houston, Texas 77225-0186, United States.
Thierry T DiaganaNovartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States.
Ujjini H ManjunathaNovartis Institute for Tropical Diseases, Novartis Institutes for BioMedical Research, Inc., Emeryville, California 94608-2916, United States.ORCID 0000-0002-7461-9303
Genomics Institute of the Novartis Research Foundation · USNovartis (United States) · USNovartis (Switzerland) · CHThe University of Texas Health Science Center at Houston · USUniversity of Maryland, Baltimore · US

Funding

Wellcome TrustWellcome Trust 219639/Z/19/Z
6 · The paper itself

Abstract

Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality in children younger than two years of age, and it is also strongly associated with childhood malnutrition and growth stunting. There is no vaccine for cryptosporidiosis and existing therapeutic options are suboptimal to prevent morbidity and mortality in young children. Recently, novel therapeutic agents have been discovered through high-throughput phenotypic and target-based screening strategies, repurposing malaria hits, etc., and these agents have a promising preclinical in vitro and in vivo anti-

Indexed as

CryptosporidiosisCryptosporidiumMalariaAdultAntiparasitic AgentsChildChild, PreschoolDiarrheaHumansAntiparasitic Agentsantiparasitic agentCHIMcryptosporidiosisCryptosporidiumdiarrheadrug discoveryhuman-challenge modelpediatric development

Identifiers

PMID33822577
PMCPMC8154424
OpenAlexW3140422546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.