Evidence map›Paper›PMID 33822431›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

A Cytotoxic Bis(1,2,3-triazol-5-ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation.

Danielle van der Westhuizen, Cathryn A Slabber, Manuel A Fernandes, Daniël F Joubert, George Kleinhans, C Johan van der Westhuizen, André Stander, Orde Q Munro, Daniela I Bezuidenhout

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. The Chemistry of Polynuclear SilverCoordination chemistry reviews · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Danielle van der WesthuizenMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 2050, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-8301-8596
Cathryn A SlabberMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 2050, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-6045-7382
Manuel A FernandesMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 2050, Johannesburg, South Africa.
Daniël F JoubertDepartment of Physiology, University of Pretoria, 0031, Pretoria, South Africa.ORCID http://orcid.org/0000-0002-7409-5212
George KleinhansMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 2050, Johannesburg, South Africa.
C Johan van der WesthuizenChemistry Department, University of Pretoria, 0028, Pretoria, South Africa.ORCID http://orcid.org/0000-0002-6377-9280
André StanderDepartment of Physiology, University of Pretoria, 0031, Pretoria, South Africa.
Orde Q MunroMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 2050, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-8979-6321
Daniela I BezuidenhoutMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, 2050, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-7776-8227
University of the Witwatersrand · ZAUniversity of Pretoria · ZACouncil for Scientific and Industrial Research · ZA

Funding

National Research Foundation, South Africa 105529National Research Foundation, South Africa 105740National Research Foundation, South Africa 108521South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa 64799
6 · The paper itself

Abstract

The syntheses of bis(triazolium)carbazole precursors and their corresponding coinage metal (Au, Ag) complexes are reported. For alkylated triazolium salts, di- or tetranuclear complexes with bridging ligands were isolated, while the bis(aryl) analogue afforded a bis(carbene) Au

Indexed as

Antineoplastic AgentsGoldDNAHumansIntercalating AgentsLigandsAntineoplastic AgentsDNAGoldIntercalating AgentsLigandsanticancercytotoxicitygold complexesmesoionic carbenesmetallodrugs

Identifiers

PMID33822431
PMCPMC8251726
OpenAlexW3142420079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.