Evidence map›Paper›PMID 33821941›Full record

ArticleAmerican journal of hypertension2021

Blood Pressure Trajectories Across the Life Course.

Norrina B Allen, Sadiya S Khan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  13. Interplay of race and neighborhood deprivation on resting and ambulatory blood pressure in young adults.American journal of physiology. Heart and circulatory physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Norrina B AllenDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Sadiya S KhanDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Northwestern University · US

Funding

Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
The Fragile Families Cardiovascular Health Follow Up StudyR01HL149869 · NHLBI · PRINCETON UNIVERSITY · PI LLOYD-JONES, DONALD M, NOTTERMAN, DANIEL A. · 2020 to 2023
$11.9M
The Claude D. Pepper Older Americans Independence Center (OAIC) at Northwestern UniversityP30AG059988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CELLA, DAVID · 2020 to 2024
$7.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Dietary sodium, inflammation, and salt sensitivity of blood pressureR01HL148661 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALLEN, NORRINA BAI, GUPTA, DEEPAK · 2019 to 2022
$3.1M
Dementia Risk Prediction Pooling ProjectR61NS120245 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALLEN, NORRINA BAI · 2020 to 2020
$1.6M
COMPARATIVE SELF-ADMINISTRATION (MONKEYS AND HUMAN)--NICOTINE AND COCAINEZ01DA000004 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HENNINGFIELD, J E · 1991 to 1991
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NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS R01 HL148661NHLBI NIH HHS R01 HL149869NIA NIH HHS P30 AG059988NIA NIH HHS R01 AG058969NINDS NIH HHS R61 NS120245
6 · The paper itself

Abstract

High blood pressure (BP) is a strong modifiable risk factor for cardiovascular disease (CVD). Longitudinal BP patterns themselves may reflect the burden of risk and vascular damage due to prolonged cumulative exposure to high BP levels. Current studies have begun to characterize BP patterns as a trajectory over an individual's lifetime. These BP trajectories take into account the absolute BP levels as well as the slope of BP changes throughout the lifetime thus incorporating longitudinal BP patterns into a single metric. Methodologic issues that need to be considered when examining BP trajectories include individual-level vs. population-level group-based modeling, use of distinct but complementary BP metrics (systolic, diastolic, mean arterial, mid, and pulse pressure), and potential for measurement errors related to varied settings, devices, and number of readings utilized. There appear to be very specific developmental periods during which divergent BP trajectories may emerge, specifically adolescence, the pregnancy period, and older adulthood. Lifetime BP trajectories are impacted by both individual-level and community-level factors and have been associated with incident hypertension, multimorbidity (CVD, renal disease, cognitive impairment), and overall life expectancy. Key unanswered questions remain around the additive predictive value of BP trajectories, intergenerational contributions to BP patterns (in utero BP exposure), and potential genetic drivers of BP patterns. The next phase in understanding BP trajectories needs to focus on how best to incorporate this knowledge into clinical care to reduce the burden of hypertensive-related outcomes and improve health equity.

Indexed as

Blood PressureCardiovascular DiseasesHeart Disease Risk FactorsHumansHypertensionblood pressurehypertensionlife coursetrajectories

Identifiers

PMID33821941
PMCPMC8022959
OpenAlexW3142235382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.